Publication Name	World Journal of Orthopedics
Manuscript ID	75682
Country	Greece

Received	2022-02-10 07:49
Peer-Review Started	2022-02-10 07:52
To Make the First Decision
Return for Revision	2022-04-13 00:20
Revised	2022-04-23 11:29
Second Decision	2022-06-08 03:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-06-14 01:04
Articles in Press	2022-06-14 01:04
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-05-31 11:28
Typeset the Manuscript	2022-06-14 02:19
Publish the Manuscript Online	2022-06-17 03:54

ISSN	2218-5836 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Topical use of tranexamic acid: Are there concerns for cytotoxicity?
Manuscript Source	Unsolicited Manuscript
All Author List	Ioannis Gkiatas, Aristeidis-Panagiotis Kontokostopoulos, Spyridon E Tsirigkakis, Ioannis Kostas-Agnantis, Ioannis Gelalis, Anastasios Korompilias and Emilios Pakos
ORCID	Author(s) ORCID Number Aristeidis-Panagiotis Kontokostopoulos http://orcid.org/0000-0001-8326-8376
Funding Agency and Grant Number
Corresponding Author	Aristeidis-Panagiotis Kontokostopoulos, MD, Academic Research, Department of Orthopaedic Surgery, University of Ioannina, Stavrou Niarchou, Ioannina 45500, Epirus, Greece. ariskontok9@gmail.com
Key Words	Tranexamic acid; Topical use; Cytotoxicity; Orthopaedic surgery
Core Tip	Tranexamic acid (TXA) is an antifibrinolytic agent and is associated with decreased blood loss in surgical procedures. It is widely used in major orthopaedic procedures in order to decrease blood transfusion needs. TXA can be administered intravenously; however, topical administration of the drug increases concentration at the operative site. There are concerns that this increased concentration may cause toxicity in the cartilage tissue. In this review, we present the recent literature regarding the cytotoxic effects of the topical administration of TXA.
Publish Date	2022-06-17 03:54
Citation	Gkiatas I, Kontokostopoulos AP, Tsirigkakis SE, Kostas-Agnantis I, Gelalis I, Korompilias A, Pakos E. Topical use of tranexamic acid: Are there concerns for cytotoxicity? World J Orthop 2022; 13(6): 555-563
URL	https://www.wjgnet.com/2218-5836/full/v13/i6/555.htm
DOI	https://dx.doi.org/10.5312/wjo.v13.i6.555

Full Article (PDF)	WJO-13-555.pdf
Full Article (Word)	WJO-13-555.docx
Manuscript File	75682_Auto_Edited-LJH_WangTQ-LS.docx
Answering Reviewers	75682-Answering reviewers.pdf
Audio Core Tip	75682-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	75682-Conflict-of-interest statement.pdf
Copyright License Agreement	75682-Copyright license agreement.pdf
Peer-review Report	75682-Peer-review(s).pdf
Scientific Misconduct Check	75682-Bing-Liu JH-2.jpg
Scientific Misconduct Check	75682-CrossCheck.jpg
Scientific Editor Work List	75682-Scientific editor work list.pdf
CrossCheck Report	75682-CrossCheck report.pdf