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Articles Published Processes
8/16/2022 11:59:52 AM | Browse: 391 | Download: 845
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Received |
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2022-03-11 01:11 |
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Peer-Review Started |
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2022-03-11 01:11 |
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To Make the First Decision |
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Return for Revision |
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2022-05-10 07:23 |
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Revised |
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2022-05-12 01:54 |
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Second Decision |
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2022-07-21 03:06 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-25 22:20 |
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Articles in Press |
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2022-07-25 22:20 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-29 06:09 |
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Publish the Manuscript Online |
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2022-08-16 11:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Basic Study |
| Article Title |
Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Qiang Cheng, Tong-Ming Liu, Peng-Fei Ren, Chang Chen, Yan-Lei Wang, Yong Dai and Xiang Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Xiang Zhang, MD, PhD, Surgeon, Surgical Oncologist, Department of General Surgery, Qilu Hospital of Shandong University, No. 107, West Wenhua Road, Jinan 250012, Shandong Province, China. xiang.zhang02@hotmail.com |
| Key Words |
Bariatric surgery; Duodenal-jejunal bypass; Farnesoid X receptor; Ceramide; Bile acids; Liver fat accumulation |
| Core Tip |
Bile acids play an important role in the amelioration of type 2 diabetes following duodenal-jejunal bypass (DJB), and are elevated significantly in the serum postoperatively. Bile acids in the peripheral circulation reflect the amount of bile acids in the gut. Therefore, a further investigation of luminal bile acids following DJB is of great significance. Here we performed DJB in a high-fat diet/streptozotocin-induced diabetic rat model and demonstrated that DJB achieved rapid and durable improvement in glucose tolerance and led to increased total luminal bile acid concentrations with preferentially increased proportion of farnesoid X receptor (FXR) - inhibitory bile acids within the common limb. Intestinal ceramide synthesis was repressed with decreased serum ceramides, and this phenomenon could be partially antagonized by luminal supplementation of FXR activating bile acid (chenodeoxycholic acid). There observations suggest a novel mechanism of bile acids in metabolic regulation after DJB. |
| Publish Date |
2022-08-16 11:59 |
| Citation |
Cheng ZQ, Liu TM, Ren PF, Chen C, Wang YL, Dai Y, Zhang X. Duodenal-jejunal bypass reduces serum ceramides via inhibiting intestinal bile acid-farnesoid X receptor pathway. World J Gastroenterol 2022; 28(31): 4328-4337 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i31/4328.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i31.4328 |
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