| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Upregulated adenosine 2A receptor accelerates post-infectious irritable bowel syndrome by promoting CD4+ T cells’ T helper 17 polarization
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Wei Dong, Zhi-Chao Ma, Jiao Fu, Bai-Li Huang, Fu-Jin Liu, Deming Sun and Cheng Lan |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81160057 |
| National Natural Science Foundation of China |
81860102 |
| National Natural Science Foundation of China |
82060102 |
|
| Corresponding Author |
Cheng Lan, MD, PhD, Chief Doctor, Professor, Department of Gastroenterology, Hainan General Hospital, Affiliated Hainan Hospital, Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China. lancheng71@163.com |
| Key Words |
Adenosine 2A receptor; CD4+ T cells; T helper 17 polarization; Post-infectious irritable bowel syndrome; Regulation |
| Core Tip |
T helper 17 (Th17) polarization occurs during the development of irritable bowel syndrome (IBS). Adenosine and its receptors participate in the development of intestinal inflammation and immune regulation. Here, we found that the intestinal levels of ATP, adenosine 2A receptor (A2AR), and interleukin-17 (IL-17) and the number of CD4+ T cells increased in post-infectious IBS (PI-IBS) mice. In addition, A2AR promoted CD4+ T cells’ IL-17 production. Upregulated A2AR accelerated PI-IBS by promoting CD4+ T cells’ Th17 polarization, which was reversed by the A2AR antagonist. Thus, our results prove that the regulation of CD4+ T cells’ Th17 polarization by A2AR plays a pathogenetic role in the development of PI-IBS. |
| Publish Date |
2022-07-04 12:30 |
| Citation |
Dong LW, Ma ZC, Fu J, Huang BL, Liu FJ, Sun D, Lan C. Upregulated adenosine 2A receptor accelerates post-infectious irritable bowel syndrome by promoting CD4+ T cells’ T helper 17 polarization. World J Gastroenterol 2022; 28(25): 2955-2967 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i25/2955.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i25.2955 |
