| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Study on the mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Jian Liu, Yan Xu, Shuai Chen, Cheng-Fei Hao, Jing Liang and Zhong-Lian Li |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Scientific and Technological Project in Key Areas of Traditional Chinese Medicine of Tianjin Municipal Health and Health Committee, China |
2019003 |
| the Integrated Traditional Chinese and Western Medicine Project of Tianjin Municipal Health and Health Committee, China |
2021042 |
|
| Corresponding Author |
Zhong-Lian Li, MD, PhD, Chief Doctor, Doctor, Doctor, Professor, Surgeon, The Second Department of Hepatobiliary and Pancreatic Surgery, Tianjin Medical University NanKai Hospital, No. 6 Changjiang Street, Nankai District, Tianjin 300102, China. nkyylzl@163.com |
| Key Words |
Yinchenhao decoction; Obstructive jaundice; Network pharmacology; Liver injury; Animal models; Oxidative stress |
| Core Tip |
Obstructive Jaundice (OJ) may cause liver injury through various mechanisms. Traditional Chinese medicine has lots of advantages in treating OJ. The mechanism of Yinchenhao decoction (YCHD) for treating OJ-induced liver injury has made significant progress in recent years, but it is still unclear. We used the network pharmacology approach to predict the active components and putative targets of YCHD. We created the OJ rat models and through randomized controlled trials, concluded that YCHD could alleviate liver injury and oxidative damage, thereby promoting the translocation of NF-E2 related factor 2 (Nrf2) to the nucleus, and upregulating the Nrf2 signaling pathway. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Liu JJ, Xu Y, Chen S, Hao CF, Liang J, Li ZL. The mechanism of Yinchenhao decoction in treating obstructive-jaundice-induced liver injury based on Nrf2 signaling pathway. World J Gastroenterol 2022; 28(32): 4635-4648 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4635.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4635 |
