| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tomoyuki Fukami, Atsushi Shiozaki, Toshiyuki Kosuga, Michihiro Kudou, Hiroki Shimizu, Takuma Ohashi, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Yukiko Morinaga, Eiichi Konishi and Eigo Otsuji |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science |
21K08689 |
| Japan Society for the Promotion of Science |
21K16456 |
| Japan Society for the Promotion of Science |
20K09016 |
| Japan Society for the Promotion of Science |
20K09084 |
| Japan Society for the Promotion of Science |
19K09202 |
| Japan Society for the Promotion of Science |
19K09182 |
|
| Corresponding Author |
Atsushi Shiozaki, MD, PhD, Assistant Professor, Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan. shiozaki@koto.kpu-m.ac.jp |
| Key Words |
Anoctamin 5; Gastric cancer; Cell cycle; G1/S checkpoint; Cell proliferation |
| Core Tip |
The present study aimed to investigate the role of Anoctamin 5 (ANO5) in the regulation of tumor progression and the clinicopathological significance of its expression in gastric cancer (GC). Immunohistochemical staining revealed that high ANO5 expression levels were associated with a poor prognosis in patients with GC. Microarray analysis results suggest that ANO5 regulates cell cycle progression by regulating the expression of cyclin-associated genes. Our results provide insights into the role of ANO5 as a mediator of and/or biomarker for GC. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Fukami T, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Ohashi T, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Morinaga Y, Konishi E, Otsuji E. Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer. World J Gastroenterol 2022; 28(32): 4649-4667 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4649.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4649 |
