Publication Name	World Journal of Gastroenterology
Manuscript ID	7597
Country	China

Received	2013-11-26 12:40
Peer-Review Started	2013-11-26 23:01
To Make the First Decision	2014-01-09 18:25
Return for Revision	2014-01-16 22:58
Revised	2014-02-07 22:44
Second Decision	2014-03-05 14:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-05 15:16
Articles in Press	2014-05-23 11:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-25 19:53
Typeset the Manuscript	2014-06-23 21:21
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	KISS1 methylation and expression as predictors of disease progression in colorectal cancer patients
Manuscript Source	Invited Manuscript
All Author List	Shao-Qin Chen, Zhi-Hua Chen, Su-Yong Lin, Qi-Bao Dai, Leng-Xi Fu and Rui-Qing Chen
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Fund of Fujian Province 2013-J01291 National Key Construction Projects Clinical Specialties
Corresponding Author	Shao-Qin Chen, MD, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Fujian Medical University, Chating Street, 20, Taijian, Fuzhou 350005, Fujian Province, China. chenshaoqin@medmail.com.cn
Key Words	Colorectal cancer; KISS1; Methylation; 5-aza-2’-deoxycytidine; Metastasis
Core Tip	KISS1 promoter methylation and expression were measured in colorectal cancer (CRC) samples to determine the effect of aberrant methylation of the KISS1 promoter during the development of CRC. We determined that KISS1 hypermethylation occurred frequently in CRC and was associated with low KISS1 expression. KISS1 methylation was associated with tumor differentiation, the depth of invasion, lymph node metastasis and distant metastasis. We treated the human HCT116 colorectal carcinoma cell line, which exhibits KISS1 promoter hypermethylation and poor KISS1 expression, with 5-aza-2’-deoxycytidine in vitro. After treatment, we observed re-expression of the KISS1 gene and decreased cell migration.
Publish Date	2014-08-07 10:34
Citation	Chen SQ, Chen ZH, Lin SY, Dai QB, Fu LX, Chen RQ. KISS1 methylation and expression as predictors of disease progression in colorectal cancer patients. World J Gastroenterol 2014; 20(29): 10071-10081
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/10071.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.10071

Full Article (PDF)	WJG-20-10071.pdf
Full Article (Word)	WJG-20-10071.doc
Manuscript File	7597-Review.doc
Answering Reviewers	7597-Answering reviewers.pdf
Copyright License Agreement	7597-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7597-Language certificate.pdf
Peer-review Report	7597-Peer review(s).pdf
Scientific Editor Work List	7597-Scientific editor work list.doc