| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yue Wu, Yu Li, Xiao-Ming Jin, Guan-Hai Dai, Xuan Chen, Ye-Ling Tong, Ze-Ming Ren, Yu Chen, Xiao-Min Xue and Ren-Zhao Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Department of Zhejiang Province |
LGF19H280008 |
| National Science and Technology Major Project of China for Significant New Drugs Development |
2016ZX09101069 |
| National Natural Science foundation of China |
81703789 |
| Science and Technology Major Project of Zhejiang Province |
2009C13032 |
|
| Corresponding Author |
Ren-Zhao Wu, MD, Chief Physician, Professor, Institute of Basic Medicine, Zhejiang Academy of Traditional Chinese Medicine, No. 132 Tianmushan Road, Xihu District, Hangzhou 310007, Zhejiang Province, China. wufeng03@126.com |
| Key Words |
Chronic atrophic gastritis; Granule Dendrobii; N-methyl-N'-nitro-N-nitrosoguanidine; Intestinal metaplasia |
| Core Tip |
Symptomatic treatment is mainly adopted for chronic atrophic gastritis (CAG) in modern medicine, and no drugs are available to promote gastric acid secretion and alleviate gastric gland atrophy. Our study shows that treatment with Granule Dendrobii (GD) for 8 wk was effective in reducing weight loss, gastric mucosal inflammation, atrophy and intestinal metaplasia, and loss of hemoglobin and erythrocytes in a rat model of CAG induced by N-methyl-N'-nitro-N-nitrosoguanidine. GD also alleviated the overexpression of PCNA and B-cell lymphoma-2 in CAG rats. These results provide new evidence on the use of GD not only for improving clinical symptoms but also for normalizing the abnormal histological changes of CAG. |
| Publish Date |
2022-08-26 07:50 |
| Citation |
Wu Y, Li Y, Jin XM, Dai GH, Chen X, Tong YL, Ren ZM, Chen Y, Xue XM, Wu RZ. Effects of Granule Dendrobii on chronic atrophic gastritis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. World J Gastroenterol 2022; 28(32): 4668-4680 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i32/4668.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i32.4668 |
