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Articles Published Processes
8/31/2022 11:27:52 AM | Browse: 861 | Download: 2570
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Received |
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2022-03-18 22:44 |
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Peer-Review Started |
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2022-03-18 22:46 |
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First Decision by Editorial Office Director |
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2022-06-11 01:33 |
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Return for Revision |
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2022-06-11 01:33 |
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Revised |
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2022-06-24 19:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-08-01 03:07 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-08-05 21:23 |
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Articles in Press |
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2022-08-05 21:23 |
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Edit the Manuscript by Language Editor |
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2022-07-28 17:06 |
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Typeset the Manuscript |
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2022-08-19 09:57 |
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Publish the Manuscript Online |
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2022-08-31 11:27 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medicine, Research & Experimental |
| Manuscript Type |
Basic Study |
| Article Title |
Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alissar Monzer, Kevork Wakimian, Farah Ballout, Samar Al Bitar, Amani Yehya, Mariam Kanso, Nour Saheb, Ayman Tawil, Samer Doughan, Maher Hussein, Deborah Mukherji, Walid Faraj, Hala Gali-Muhtasib and Wassim Abou-Kheir |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Wassim Abou-Kheir, MSc, PhD, Associate Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss street-Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb |
| Key Words |
Diiminoquinone; Anticancer activity; Colorectal cancer; Cancer stem cells; Patient-derived organoids; Colonospheres |
| Core Tip |
Diiminoquinone has anticancer activity against colorectal cancer. Diiminoquinone targets chemoresistant cancer stem cells in three-dimensional in vitro models by downregulating the main components of stem cell-related -catenin, AKT, and ERK oncogenic signaling pathways. Our findings highlight diiminoquinone’s novel therapeutic potential against colorectal cancer. |
| Publish Date |
2022-08-31 11:27 |
| Citation |
Monzer A, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Gali-Muhtasib H, Abou-Kheir W. Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models. World J Gastroenterol 2022; 28(33): 4787-4811
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| URL |
https://www.wjgnet.com/1007-9327/full/v28/i33/4787.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i33.4787 |
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