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8/31/2022 11:27:52 AM | Browse: 253 | Download: 831
Publication Name World Journal of Gastroenterology
Manuscript ID 76258
Country/Territory Lebanon
Received
2022-03-18 22:44
Peer-Review Started
2022-03-18 22:46
To Make the First Decision
Return for Revision
2022-06-11 01:33
Revised
2022-06-24 19:35
Second Decision
2022-08-01 03:07
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-05 21:23
Articles in Press
2022-08-05 21:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-07-28 17:06
Typeset the Manuscript
2022-08-19 09:57
Publish the Manuscript Online
2022-08-31 11:27
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models
Manuscript Source Invited Manuscript
All Author List Alissar Monzer, Kevork Wakimian, Farah Ballout, Samar Al Bitar, Amani Yehya, Mariam Kanso, Nour Saheb, Ayman Tawil, Samer Doughan, Maher Hussein, Deborah Mukherji, Walid Faraj, Hala Gali-Muhtasib and Wassim Abou-Kheir
ORCID
Author(s) ORCID Number
Samar Al Bitar http://orcid.org/0000-0002-0016-1029
Samer Doughan http://orcid.org/0000-0002-6584-6977
Deborah Mukherji http://orcid.org/0000-0002-0192-5828
Walid Faraj http://orcid.org/0000-0002-0156-7960
Hala Gali-Muhtasib http://orcid.org/0000-0001-6840-3015
Wassim Abou-Kheir http://orcid.org/0000-0001-9719-9324
Funding Agency and Grant Number
Corresponding Author Wassim Abou-Kheir, MSc, PhD, Associate Professor, Department of Anatomy, Cell Biology and Physiological Sciences, American University of Beirut, Bliss street-Hamra, Beirut 1107-2020, Lebanon. wa12@aub.edu.lb
Key Words Diiminoquinone; Anticancer activity; Colorectal cancer; Cancer stem cells; Patient-derived organoids; Colonospheres
Core Tip Diiminoquinone has anticancer activity against colorectal cancer. Diiminoquinone targets chemoresistant cancer stem cells in three-dimensional in vitro models by downregulating the main components of stem cell-related -catenin, AKT, and ERK oncogenic signaling pathways. Our findings highlight diiminoquinone’s novel therapeutic potential against colorectal cancer.
Publish Date 2022-08-31 11:27
Citation Monzer A, Wakimian K, Ballout F, Al Bitar S, Yehya A, Kanso M, Saheb N, Tawil A, Doughan S, Hussein M, Mukherji D, Faraj W, Gali-Muhtasib H, Abou-Kheir W. Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensional in vitro models. World J Gastroenterol 2022; 28(33): 4787-4811
URL https://www.wjgnet.com/1007-9327/full/v28/i33/4787.htm
DOI https://dx.doi.org/10.3748/wjg.v28.i33.4787
Full Article (PDF) WJG-28-4787.pdf
Full Article (Word) WJG-28-4787.docx
Manuscript File 76258_Auto_Edited-ZMG-Filipodia-LS.docx
Answering Reviewers 76258-Answering reviewers.pdf
Audio Core Tip 76258-Audio core tip.mp3
Biostatistics Review Certificate 76258-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76258-Conflict-of-interest statement.pdf
Copyright License Agreement 76258-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 76258-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 76258-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 76258-Language certificate.pdf
Supplementary Material 76258-Supplementary material.pdf
Peer-review Report 76258-Peer-review(s).pdf
Scientific Misconduct Check 76258-CrossCheck.png
Scientific Misconduct Check 76258-Bing-Gong ZM-2.jpg
Scientific Editor Work List 76258-Scientific editor work list.pdf