Publication Name	World Journal of Gastroenterology
Manuscript ID	7628
Country	China

Received	2013-11-27 14:58
Peer-Review Started	2013-11-27 20:01
To Make the First Decision	2014-01-09 18:28
Return for Revision	2014-01-20 21:51
Revised	2014-02-18 16:02
Second Decision	2014-03-13 16:18
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-13 16:32
Articles in Press	2014-05-23 11:21
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-18 11:42
Typeset the Manuscript	2014-06-26 19:41
Publish the Manuscript Online	2014-08-07 10:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression
Manuscript Source	Invited Manuscript
All Author List	Qing-Yu Zhang, Ran Li, Guo-Fang Zeng, Bin Liu, Jie Liu, Yang Shu, Zhong-Kao Liu, Zhi-Dong Qiu, Dong-Jun Wang, Hui-Lai Miao, Ming-Yi Li and Run-Zhi Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81041099 Natural Science Foundation of Guangdong Province, China S2011010003750
Corresponding Author	Run-Zhi Zhu, PhD, Key Laboratory of Hepatic Disease, Affiliated Hospital of Guangdong Medical College, No. 57 Renmin Road, Zhanjiang 524001, Guangdong Province, China. hepatolab@163.com
Key Words	Dihydromyricetin; Migration; Invasion; Hepatic cancer; Matrix metalloproteinase-9
Core Tip	The novel findings of this report are that dihydromyricetin (DHM) can strongly inhibit the migration and invasion (in transwell experiments) of the hepatic cancer cell lines SK-Hep-1 and MHCC97L. Western blot analysis showed that DHM down-regulated the level of matrix metalloproteinase 9 (MMP-9) protein but had little effect on the expression of MMP-2. Further investigation indicated that this reduction of MMP-9 expression underlies the inhibitory effects of DHM on cell migration and invasion and that this decrease was associated with an increase in the total protein levels of PKC-? and decrease in the protein phosphorylation levels of members of the MAPK signaling pathway.
Publish Date	2014-08-07 10:34
Citation	Zhang QY, Li R, Zeng GF, Liu B, Liu J, Shu Y, Liu ZK, Qiu ZD, Wang DJ, Miao HL, Li MY, Zhu RZ. Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression. World J Gastroenterol 2014; 20(29): 10082-10093
URL	http://www.wjgnet.com/1007-9327/full/v20/i29/10082.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i29.10082

Full Article (PDF)	WJG-20-10082.pdf
Full Article (Word)	WJG-20-10082.doc
Manuscript File	7628-Review.doc
Answering Reviewers	7628-Answering reviewers.pdf
Copyright License Agreement	7628-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7628-Language certificate.pdf
Peer-review Report	7628-Peer review(s).pdf
Scientific Editor Work List	7628-Scientific editor work list.doc