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8/25/2014 2:47:00 PM | Browse: 407 | Download: 377
Publication Name World Journal of Gastroenterology
Manuscript ID 7628
Country of Manuscript Source China
Received
2013-11-27 14:58
Peer-Review Started
2013-11-27 20:01
To Make the First Decision
2014-01-09 18:28
Return for Revision
2014-01-20 21:51
Revised
2014-02-18 16:02
Second Decision
2014-03-13 16:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-03-13 16:32
Articles in Press
2014-05-23 11:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-04-18 11:42
Typeset the Manuscript
2014-06-26 19:41
Publish the Manuscript Online
2014-08-07 10:34
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Oncology
Manuscript Type Autobiography
Article Title Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression
Manuscript Source Invited Manuscript
All Author List Qing-Yu Zhang, Ran Li, Guo-Fang Zeng, Bin Liu, Jie Liu, Yang Shu, Zhong-Kao Liu, Zhi-Dong Qiu, Dong-Jun Wang, Hui-Lai Miao, Ming-Yi Li and Run-Zhi Zhu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81041099
Natural Science Foundation of Guangdong Province, China S2011010003750
Corresponding author Run-Zhi Zhu, PhD, Key Laboratory of Hepatic Disease, Affiliated Hospital of Guangdong Medical College, No. 57 Renmin Road, Zhanjiang 524001, Guangdong Province, China. hepatolab@163.com
Keywords Dihydromyricetin; Migration; Invasion; Hepatic cancer; Matrix metalloproteinase-9
Core Tip The novel findings of this report are that dihydromyricetin (DHM) can strongly inhibit the migration and invasion (in transwell experiments) of the hepatic cancer cell lines SK-Hep-1 and MHCC97L. Western blot analysis showed that DHM down-regulated the level of matrix metalloproteinase 9 (MMP-9) protein but had little effect on the expression of MMP-2. Further investigation indicated that this reduction of MMP-9 expression underlies the inhibitory effects of DHM on cell migration and invasion and that this decrease was associated with an increase in the total protein levels of PKC-? and decrease in the protein phosphorylation levels of members of the MAPK signaling pathway.
Publish Date 2014-08-07 10:34
Citation Zhang QY, Li R, Zeng GF, Liu B, Liu J, Shu Y, Liu ZK, Qiu ZD, Wang DJ, Miao HL, Li MY, Zhu RZ. Dihydromyricetin inhibits migration and invasion of hepatoma cells through regulation of MMP-9 expression. World J Gastroenterol 2014; 20(29): 10082-10093
Url http://www.wjgnet.com/1007-9327/full/v20/i29/10082.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i29.10082
Full Article (PDF) WJG-20-10082.pdf
Full Article (Word) WJG-20-10082.doc
Manuscript File 7628-Review.doc
Answering Reviewers 7628-Answering reviewers.pdf
Copyright License Agreement 7628-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 7628-Language certificate.pdf
Peer-review Report 7628-Peer review(s).pdf
Scientific Editor Work List 7628-Scientific editor work list.doc