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Articles Published Processes
9/9/2022 3:45:24 PM | Browse: 402 | Download: 1100
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Received |
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2022-03-11 17:33 |
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Peer-Review Started |
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2022-03-11 17:35 |
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To Make the First Decision |
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Return for Revision |
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2022-04-25 22:15 |
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Revised |
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2022-05-13 07:27 |
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Second Decision |
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2022-08-18 03:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-22 19:16 |
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Articles in Press |
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2022-08-22 19:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-08-04 17:17 |
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Typeset the Manuscript |
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2022-09-04 11:00 |
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Publish the Manuscript Online |
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2022-09-09 15:45 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Christian Carpéné, Kristiyan Stiliyanov Atanasov, Francisco Les and Josep Mercader Barcelo |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Christian Carpéné, PhD, Senior Researcher, Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1297, Université Paul Sabatier Toulouse III,
CHU Rangueil, Bat L4, BP 84225, Toulouse 31432, France. christian.carpene@inserm.fr |
| Key Words |
Diabetes; Adipocytes; Amine oxidases; Insulin-like agents; Glucose transport; Polydipsia |
| Core Tip |
In adipocytes, benzylamine (Bza) is oxidized by amine oxidases and stimulates glucose uptake. Bza oral administration alleviates insulin-resistant diabetes in obese and diabetic mice. It was investigated whether Bza was also antihyperglycemic in insulin-deficient type 1 diabetes. To this aim, a 0.5% Bza drinking solution was given to streptozotocin-induced diabetic mice. Oral Bza did not recover hyperglycemia and reduced adiposity of lipoatrophic and diabetic mice. A minimal level of adiposity was required to support benzylamine oxidation and to improve glucose utilization. Thus, the antidiabetic properties of Bza in obese and diabetic models, do not apply for diabetes with severe lipoatrophy. |
| Publish Date |
2022-09-09 15:45 |
| Citation |
Carpéné C, Stiliyanov Atanasov K, Les F, Mercader Barcelo J. Hyperglycemia and reduced adiposity of streptozotocin-induced diabetic mice are not alleviated by oral benzylamine supplementation. World J Diabetes 2022; 13(9): 752-764 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i9/752.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i9.752 |
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