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Articles Published Processes
9/9/2022 12:48:14 PM | Browse: 409 | Download: 1358
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Received |
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2022-03-14 08:12 |
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Peer-Review Started |
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2022-03-14 08:13 |
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To Make the First Decision |
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Return for Revision |
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2022-04-17 03:26 |
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Revised |
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2022-04-29 02:07 |
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Second Decision |
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2022-08-11 03:01 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-16 06:02 |
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Articles in Press |
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2022-08-16 06:02 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-08-22 06:00 |
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Publish the Manuscript Online |
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2022-09-09 12:48 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Evidence-Based Medicine |
| Article Title |
Prediction of gastric cancer risk by a polygenic risk score of Helicobacter pylori
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Xiao-Yu Wang, Li-Li Wang, Shu-Zhen Liang, Chao Yang, Lin Xu, Meng-Chao Yu, Yi-Xuan Wang and Quan-Jiang Dong |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
31870777 |
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| Corresponding Author |
Quan-Jiang Dong, MD, PhD, Chief Doctor, Professor, Central Laboratories and Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao University, No. 5 Donghai Middle Road, Qingdao 266071, Shandong Province, China. allyking114@126.com |
| Key Words |
Polygenic risk scores; Helicobacter pylori; Gastric cancer; Single nucleotide polymorphism |
| Core Tip |
Prediction of cancer risk is of importance in the clinical management of populations with a high risk of gastric cancer. This study constructed a polygenic risk score (PRS) model based on Helicobacter pylori (H. pylori) single nucleotide polymorphisms (SNPs) to predict the risk of gastric cancer. Associations between previously reported H. pylori SNPs and gastric cancer were validated in global strains. A PRS model constructed with validated SNPs had a high predictive power for gastric cancer at a global level and for individuals infected with hpEurope strains. It has potential for clinical use in the management of the H. pylori infection. |
| Publish Date |
2022-09-09 12:48 |
| Citation |
Wang XY, Wang LL, Liang SZ, Yang C, Xu L, Yu MC, Wang YX, Dong QJ. Prediction of gastric cancer risk by a polygenic risk score of Helicobacter pylori. World J Gastrointest Oncol 2022; 14(9): 1844-1855 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i9/1844.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i9.1844 |
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