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8/26/2022 1:20:16 PM | Browse: 262 | Download: 582
Publication Name World Journal of Stem Cells
Manuscript ID 76465
Country Pakistan
Received
2022-03-18 18:24
Peer-Review Started
2022-03-18 18:25
To Make the First Decision
Return for Revision
2022-04-25 22:32
Revised
2022-05-09 11:57
Second Decision
2022-07-06 08:08
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-07-11 18:56
Articles in Press
2022-07-11 18:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
2022-07-02 22:48
Typeset the Manuscript
2022-08-22 01:06
Publish the Manuscript Online
2022-08-26 13:20
ISSN 1948-0210 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Cell Biology
Manuscript Type Basic Study
Article Title Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model
Manuscript Source Invited Manuscript
All Author List Rida-e-Maria Qazi, Irfan Khan, Kanwal Haneef, Tuba Shakil Malick, Nadia Naeem, Waqas Ahmad, Asmat Salim and Sadia Mohsin
ORCID
Author(s) ORCID Number
Rida-e-Maria Qazi http://orcid.org/0000-0002-0458-0263
Irfan Khan http://orcid.org/0000-0003-1878-7836
Kanwal Haneef http://orcid.org/0000-0002-4725-4281
Tuba Shakil Malick http://orcid.org/0000-0002-3856-451X
Nadia Naeem http://orcid.org/0000-0003-1970-7340
Waqas Ahmad http://orcid.org/0000-0002-3291-0629
Asmat Salim http://orcid.org/0000-0001-5181-0458
Sadia Mohsin http://orcid.org/0000-0002-2106-1094
Funding Agency and Grant Number
Corresponding Author Asmat Salim, PhD, Professor, Stem Cell Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Main University Road, Karachi 75270, Sindh, Pakistan. asmat.salim@iccs.edu
Key Words Mesenchymal stem cells; Myocardial infarction; Cardiac tissue engineering; Demethylating agent; Collagen scaffold; Zebularine
Core Tip This study was designed to elucidate the effect of three-dimensional (3D) microenvironment provided by the use of natural collagen based scaffold and DNA methyl transferase inhibitor, zebularine, on the cardiac differentiation of mesenchymal stem cells (MSCs) in vitro and cardiac regeneration in vivo. Collagen scaffold provides a native 3D microenvironment to MSCs and along with zebularine, enhances their cardiac differentiation potential. Transplantation of zebularine treated MSC-seeded collagen scaffold in the rat myocardial infarction (MI) model aids in improving cardiac function and preserves left ventricular remodeling. Translation of this research into clinics can be a better option for the treatment of MI.
Publish Date 2022-08-26 13:20
Citation Qazi REM, Khan I, Haneef K, Malick TS, Naeem N, Ahmad W, Salim A, Mohsin S. Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model. World J Stem Cells 2022; 14(8): 633-657
URL https://www.wjgnet.com/1948-0210/full/v14/i8/633.htm
DOI https://dx.doi.org/10.4252/wjsc.v14.i8.633
Full Article (PDF) WJSC-14-633.pdf
Full Article (Word) WJSC-14-633.docx
The ARRIVE Guidelines 76465-The-ARRIVE-Guidelines-revision.pdf
Manuscript File 76465_Auto_Edited-JRF-Filipodia CL-LS.docx
Answering Reviewers 76465-Answering reviewers.pdf
Audio Core Tip 76465-Audio core tip.m4a
Biostatistics Review Certificate 76465-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 76465-Conflict-of-interest statement.pdf
Copyright License Agreement 76465-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 76465-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 76465-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 76465-Language certificate.pdf
Peer-review Report 76465-Peer-review(s).pdf
Scientific Misconduct Check 76465-Bing-Fan JR-2.png
Scientific Editor Work List 76465-Scientific editor work list.pdf