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Articles Published Processes
8/26/2022 1:20:16 PM | Browse: 412 | Download: 984
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Received |
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2022-03-18 18:24 |
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Peer-Review Started |
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2022-03-18 18:25 |
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To Make the First Decision |
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Return for Revision |
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2022-04-25 22:32 |
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Revised |
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2022-05-09 11:57 |
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Second Decision |
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2022-07-06 08:08 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-07-11 18:56 |
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Articles in Press |
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2022-07-11 18:56 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-07-02 22:48 |
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Typeset the Manuscript |
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2022-08-22 01:06 |
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Publish the Manuscript Online |
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2022-08-26 13:20 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Rida-e-Maria Qazi, Irfan Khan, Kanwal Haneef, Tuba Shakil Malick, Nadia Naeem, Waqas Ahmad, Asmat Salim and Sadia Mohsin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Asmat Salim, PhD, Professor, Stem Cell Laboratory, Dr. Panjwani Center for Molecular Medicine and Drug Research, ICCBS, University of Karachi, Main University Road, Karachi 75270, Sindh, Pakistan. asmat.salim@iccs.edu |
| Key Words |
Mesenchymal stem cells; Myocardial infarction; Cardiac tissue engineering; Demethylating agent; Collagen scaffold; Zebularine |
| Core Tip |
This study was designed to elucidate the effect of three-dimensional (3D) microenvironment provided by the use of natural collagen based scaffold and DNA methyl transferase inhibitor, zebularine, on the cardiac differentiation of mesenchymal stem cells (MSCs) in vitro and cardiac regeneration in vivo. Collagen scaffold provides a native 3D microenvironment to MSCs and along with zebularine, enhances their cardiac differentiation potential. Transplantation of zebularine treated MSC-seeded collagen scaffold in the rat myocardial infarction (MI) model aids in improving cardiac function and preserves left ventricular remodeling. Translation of this research into clinics can be a better option for the treatment of MI. |
| Publish Date |
2022-08-26 13:20 |
| Citation |
Qazi REM, Khan I, Haneef K, Malick TS, Naeem N, Ahmad W, Salim A, Mohsin S. Combination of mesenchymal stem cells and three-dimensional collagen scaffold preserves ventricular remodeling in rat myocardial infarction model. World J Stem Cells 2022; 14(8): 633-657 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i8/633.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i8.633 |
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