Publication Name	World Journal of Meta-Analysis
Manuscript ID	7647
Country	Canada

Received	2013-11-27 16:39
Peer-Review Started	2013-11-28 09:57
To Make the First Decision	2014-03-12 16:58
Return for Revision	2014-03-20 20:09
Revised	2014-05-01 09:19
Second Decision	2014-05-29 08:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-05-29 09:38
Articles in Press	2014-05-29 11:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-09-02 16:43
Publish the Manuscript Online	2014-09-25 11:49

ISSN	2308-3840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Orthopedics
Manuscript Type	Meta-Analysis
Article Title	Efficacy of therapeutic ultrasound vs sham ultrasound on pain and physical function in people with knee osteoarthritis: A meta-analysis of randomized controlled trials
Manuscript Source	Invited Manuscript
All Author List	Norma J MacIntyre, Ahmed Negm, Adalberto Loyola-Sánchez and Mohit Bhandari
Funding Agency and Grant Number	Funding Agency Grant Number Canadian Institutes of Health Research Randomized Controlled Trials Mentorship Program MTP 108229(to NJM, MB)
Corresponding Author	Norma J. MacIntyre, BSc(PT), MSc, PhD Associate Professor, School of Rehabilitation Science, IAHS 403, 1400 Main St W, Hamilton, ON L8S 1C7, Canada macint@mcmaster.ca
Key Words	Ultrasonic therapy; Physical therapy modalities; Osteoarthritis; Double-blind method; Evidence-based medicine
Core Tip	Controversy exists regarding the efficacy of therapeutic ultrasound in the management of knee osteoarthritis (OA). Lack of participant blinding in effectiveness trials introduces bias known to exaggerate treatment effect estimates particularly for outcomes such as pain and self-reported physical function. We meta-analyzed data from double- and triple-blind trials only and high level evidence shows that therapeutic ultrasound decreases knee OA pain but does not increase physical function immediately following treatment. Due to the methodological quality of the included trials, we conclude that a large well-designed trial is required before this clinical question can be answered definitively.
Publish Date	2014-09-25 11:49
Citation	MacIntyre NJ, Negm A, Loyola-Sánchez A, Bhandari M. Efficacy of therapeutic ultrasound vs sham ultrasound on pain and physical function in people with knee osteoarthritis: A meta-analysis of randomized controlled trials. World J Meta-Anal 2014; 2(3): 78-90
URL	http://www.wjgnet.com/2308-3840/full/v2/i3/78.htm
DOI	http://dx.doi.org/10.13105/wjma.v2.i3.78

Full Article (PDF)	WJMA-2-78.pdf
Full Article (Word)	WJMA-2-78.doc
Manuscript File	7647-Review.doc
Answering Reviewers	7647-Answering reviewers.pdf
Copyright License Agreement	7647-Copyright assignment.pdf
Peer-review Report	7647-Peer review(s).pdf
Scientific Misconduct Check	7647-CrossCheck.jpg
Scientific Editor Work List	7647-Scientific editor work list.pdf