Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Helicobacter pylori isolates from ethnic minority patients in Guangxi: Resistance rates, mechanisms, and genotype
|
Manuscript Source |
Invited Manuscript |
All Author List |
Li-Juan Zhao, Yan-Qiang Huang, Bing-Pu Chen, Xiao-Qiang Mo, Zan-Song Huang, Xiao-Feng Huang, Lian-Deng Wei, Hong-Yu Wei, Yuan-Hong Chen, Hua-Ying Tang, Gan-Rong Huang, Yan-Chun Qin, Xiao-Hua Li and Lu-Yao Wang |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
Nature Science Foundation of Guangxi |
2012GXNSFAA053172 |
School to School and Enterprise to build the innovation platform in 2013, Guangxi Scientific Research |
2013-8 |
|
Corresponding Author |
Yan-Qiang Huang, Associate Professor, Department of Medical Microbiology and Immunology, You Jiang Medical College for Nationalities, 98 Countryside Road, Baise 533000, Guangxi Zhuang Autonomous Region, China. hyq77615@163.com |
Key Words |
Helicobacter pylori; Antibiotic resistance; Mechanism; Clarithromycin; Genotype |
Core Tip |
The present study showed that the rate of Helicobacter pylori (H. pylori) resistance to clarithromycin was 31.3% in ethnic minority patients in Guangxi, slightly higher than that in Dongguan in 2009 but significantly higher than the reported resistance rate in 2008 in the same region (Guangxi). The significant increase in the rate of H. pylori resistance to clarithromycin in this region may be caused by the long-term and/or wide use of clarithromycin, which can decrease the populations of sensitive bacteria and promote the propagation of drug-resistant bacteria. Of note, this study also found that there existed multidrug resistant H. pylori strains (resistant to amoxicillin, metronidazole, tetracycline, and levofloxacin). |
Publish Date |
2014-04-29 09:53 |
Citation |
Zhao LJ, Huang YQ, Chen BP, Mo XQ, Huang ZS, Huang XF, Wei LD, Wei HY, Chen YH, Tang HY, Huang GR, Qin YC, Li XH, Wang LY. Helicobacter pylori isolates from ethnic minority patients in Guangxi: Resistance rates, mechanisms, and genotype. World J Gastroenterol 2014; 20(16): 4761-4770 |
URL |
http://www.wjgnet.com/1007-9327/full/v20/i16/4761.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v20.i16.4761 |