Publication Name	World Journal of Gastroenterology
Manuscript ID	7667
Country	Japan

Received	2013-11-28 12:06
Peer-Review Started	2013-11-28 13:03
To Make the First Decision	2013-12-16 18:06
Return for Revision	2013-12-17 15:47
Revised	2014-01-07 14:30
Second Decision	2014-01-20 18:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-01-20 19:20
Articles in Press	2014-05-23 11:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-30 14:19
Publish the Manuscript Online	2014-06-21 13:56

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Kouichi Miura and Hirohide Ohnishi
Funding Agency and Grant Number	Funding Agency Grant Number JSPS to Miura K
Corresponding Author	Kouichi Miura, MD, PhD, Department of Gastroenterology, Akita University Graduate School of Medicine, 1-1-1 Hondo Akita-shi, Akita 010-8543, Japan. miura116@doc.med.akita-u.ac.jp
Key Words	Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Gut microbiota; Toll-like receptor; Probiotics; Prebiotics
Core Tip	The gut-liver axis has attracted much interest particularly regarding the pathogenesis of nonalcoholic fatty liver disease (NAFLD) because gut microbiota contribute to nutritional absorption and storage. In addition, gut microbiota are a source of Toll-like receptor (TLR) ligands, which can stimulate liver cells to produce proinflammatory cytokines. To date, TLR2, TLR4, TLR5, and TLR9 have been shown to be associated with the pathogenesis of NAFLD. The present article reviewed the current understanding of gut microbiota and TLR signaling in NAFLD and potential treatment targeted at gut microbiota and TLRs.
Publish Date	2014-06-21 13:56
Citation	Miura K, Ohnishi H. Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20(23): 7381-7391
URL	http://www.wjgnet.com/1007-9327/full/v20/i23/7381.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i23.7381

Full Article (PDF)	WJG-20-7381.pdf
Full Article (Word)	WJG-20-7381.doc
Manuscript File	7667-Review.doc
Answering Reviewers	7667-Answering reviewers.pdf
Copyright License Agreement	7667-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7667-Language certificate.pdf
Peer-review Report	7667-Peer review(s).pdf
Scientific Editor Work List	7667-Scientific editor work list.doc