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Articles Published Processes
7/26/2022 11:15:04 AM | Browse: 347 | Download: 945
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Received |
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2022-03-30 14:40 |
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Peer-Review Started |
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2022-03-30 14:42 |
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To Make the First Decision |
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Return for Revision |
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2022-04-25 22:21 |
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Revised |
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2022-05-04 08:42 |
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Second Decision |
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2022-06-17 03:04 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-06-20 17:17 |
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Articles in Press |
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2022-06-20 17:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-07-22 07:55 |
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Publish the Manuscript Online |
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2022-07-26 11:15 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Na Dong, Pan-Pan Zhou, Dong Li, Hua-Su Zhu, Ling-Hong Liu, Hui-Xian Ma, Qing Shi and Xiu-Li Ju |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Rongxiang Regenerative Medicine Foundation of Shandong University |
2019SDRX-18 |
| Clinical Practical New Technology Development Found of Qilu Hospital of Shandong University |
KYC 2019-0057 |
| Clinical Research Center of Shandong University |
2020SDUCRCA010 |
| Natural Science Foundation of Shandong Province |
ZR2020MH063 |
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| Corresponding Author |
Xiu-Li Ju, PhD, Chief Doctor, Department of Pediatrics, Qilu Hospital of Shandong University, No. 107 Wenhua West Road, Jinan 250012, Shandong Province, China. jxlqlyy@163.com |
| Key Words |
Mesenchymal stem cell; Hyperoxia; Multiple organ injury; Bronchopulmonary dysplasia; Heme oxygenase-1; JAK/STAT pathway |
| Core Tip |
In the present study, we used a newborn rat model of postnatal hyperoxia exposure to simulate clinical bronchopulmonary dysplasia (BPD) and the associated heart and kidney injuries in preterm infants. Improved lung, heart, and kidney development, as well as reduced inflammatory and oxidative responses, were observed with human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) administration. We demonstrated that hUC-MSCs ameliorate hyperoxia-induced systemic organ injuries by activating heme oxygenase-1 expression and JAK/STAT pathway. Overall, our study shows that intratracheal administration is a more attractive route of MSCs administration in preterm infants for the prevention and treatment of BPD and hyperoxia-induced systemic damage. |
| Publish Date |
2022-07-26 11:15 |
| Citation |
Dong N, Zhou PP, Li D, Zhu HS, Liu LH, Ma HX, Shi Q, Ju XL. Intratracheal administration of umbilical cord-derived mesenchymal stem cells attenuates hyperoxia-induced multi-organ injury via heme oxygenase-1 and JAK/STAT pathways. World J Stem Cells 2022; 14(7): 556-576 |
| URL |
https://www.wjgnet.com/1948-0210/full/v14/i7/556.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v14.i7.556 |
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