Publication Name	World Journal of Diabetes
Manuscript ID	7684
Country	China

Received	2013-11-28 14:36
Peer-Review Started	2013-11-29 13:23
To Make the First Decision	2014-03-12 16:57
Return for Revision	2014-03-20 20:10
Revised	2014-04-10 19:59
Second Decision	2014-07-29 08:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-07-29 09:03
Articles in Press	2014-07-29 09:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-06 23:22
Typeset the Manuscript	2014-10-14 16:28
Publish the Manuscript Online	2014-12-13 19:01

ISSN	1948-9358 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms
Manuscript Source	Invited Manuscript
All Author List	Jieli Lu, Rami Jaafer, Rémy Bonnavion, Philippe Bertolino and Chang-Xian Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Agence National de Recherche ANR 2010 BLAN 1240 01 Ligue contre le Cancer du Rhône and de la Loire CMIRA program of Region Rhône-Alpes 12004959-01 Fondation ARC pour la Recherche sur le Cancer, France SFI20101201530 National Nature Science Foundation of China NSFC81170719 National Nature Science Foundation of China 81370960 Shanghai New Excellent Youth Program XYQ2011009
Corresponding Author	Jieli Lu, MD, PhD, Sino-French Life Science and Genomic Center, the E-Institute of Shanghai, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, Xuhui District, Shanghai 200025, China. jielilu@hotmail.com
Key Words	α-cell; β-cell; Transdifferentiation; Diabetes mellitus; Cell-replacement therapy
Core Tip	Recent works highlighted the phenomenon of transdifferentiation of pancreatic α cells into β cells, which has drawn much attention in the field. Considering that α-cell transdifferentiation could be used as a new strategy of cell replacement therapy for the treatment of diabetes, because of the presence of α cells in the pancreas of both type 1 and 2 diabetics, we believe that it is relevant to elucidate the cellular and molecular events in α- to β-cell conversion. Our review focuses on the recent experimental α-cell transdifferentiation models, highlighting the insight provided by these works into the candidates and contexts revealed to be involved in this process.
Publish Date	2014-12-13 19:01
Citation	Lu J, Jaafer R, Bonnavion R, Bertolino P, Zhang CX. Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms. World J Diabetes 2014; 5(6): 847-853
URL	http://www.wjgnet.com/1948-9358/full/v5/i6/847.htm
DOI	http://dx.doi.org/10.4239/wjd.v5.i6.847

Full Article (PDF)	WJD-5-847.pdf
Full Article (Word)	WJD-5-847.doc
Manuscript File	7684-Review.doc
Answering Reviewers	7684-Answering reviewers.pdf
Copyright License Agreement	7684-Copyright assignment.pdf
Peer-review Report	7684-Peer review(s).pdf
Scientific Misconduct Check	7684-CrossCheck.jpg
Scientific Editor Work List	7684-Scientific editor work list.pdf