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Articles Published Processes
12/13/2014 7:02:00 PM | Browse: 1187 | Download: 1500
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Received |
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2013-11-28 14:36 |
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Peer-Review Started |
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2013-11-29 13:23 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2014-03-20 20:10 |
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Revised |
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2014-04-10 19:59 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2014-07-29 08:35 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2014-07-29 09:03 |
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Articles in Press |
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2014-07-29 09:03 |
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Edit the Manuscript by Language Editor |
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2014-08-06 23:22 |
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Typeset the Manuscript |
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2014-10-14 16:28 |
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Publish the Manuscript Online |
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2014-12-13 19:01 |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Review |
| Article Title |
Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jieli Lu, Rami Jaafer, Rémy Bonnavion, Philippe Bertolino and Chang-Xian Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Agence National de Recherche |
ANR 2010 BLAN 1240 01 |
| Ligue contre le Cancer du Rhône and de la Loire |
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| CMIRA program of Region Rhône-Alpes |
12004959-01 |
| Fondation ARC pour la Recherche sur le Cancer, France |
SFI20101201530 |
| National Nature Science Foundation of China |
NSFC81170719 |
| National Nature Science Foundation of China |
81370960 |
| Shanghai New Excellent Youth Program |
XYQ2011009 |
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| Corresponding Author |
Jieli Lu, MD, PhD, Sino-French Life Science and Genomic Center, the E-Institute of Shanghai, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University, Xuhui District, Shanghai 200025, China. jielilu@hotmail.com
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| Key Words |
α-cell; β-cell; Transdifferentiation; Diabetes mellitus; Cell-replacement therapy |
| Core Tip |
Recent works highlighted the phenomenon of transdifferentiation of pancreatic α cells into β cells, which has drawn much attention in the field. Considering that α-cell transdifferentiation could be used as a new strategy of cell replacement therapy for the treatment of diabetes, because of the presence of α cells in the pancreas of both type 1 and 2 diabetics, we believe that it is relevant to elucidate the cellular and molecular events in α- to β-cell conversion. Our review focuses on the recent experimental α-cell transdifferentiation models, highlighting the insight provided by these works into the candidates and contexts revealed to be involved in this process.
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| Publish Date |
2014-12-13 19:01 |
| Citation |
Lu J, Jaafer R, Bonnavion R, Bertolino P, Zhang CX. Transdifferentiation of pancreatic α-cells into insulin-secreting cells: From experimental models to underlying mechanisms. World J Diabetes 2014; 5(6): 847-853 |
| URL |
http://www.wjgnet.com/1948-9358/full/v5/i6/847.htm |
| DOI |
http://dx.doi.org/10.4239/wjd.v5.i6.847 |
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