Publication Name	World Journal of Gastroenterology
Manuscript ID	7693
Country	United States

Received	2013-11-28 15:45
Peer-Review Started	2013-11-29 17:44
To Make the First Decision	2014-01-24 14:40
Return for Revision	2014-01-26 15:22
Revised	2014-02-21 07:09
Second Decision	2014-04-03 10:18
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-04-03 12:36
Articles in Press	2014-05-23 10:27
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-08-27 09:03
Typeset the Manuscript	2014-11-25 10:15
Publish the Manuscript Online	2014-12-10 15:52

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Ru Chen, Sheng Pan, Keith Lai, Lisa A Lai, David A Crispin, Mary P Bronner and Teresa A Brentnall
Funding Agency and Grant Number	Funding Agency Grant Number National Institutes of Health R21CA164548 Crohn’s and Colitis Foundation of America
Corresponding Author	Ru Chen, PhD, Department of Medicine, University of Washington, Schmitz Hall, Box 355840, Seattle, WA 98195, United States. ruchen@u.washington.edu
Key Words	Ulcerative colitis; Colorectal cancer; Inflammation; Oxidative stress; Tumor necrosis factor receptor-associated protein 1
Core Tip	Chronic ulcerative colitis (UC) is an inflammatory bowel disease that predisposes to colorectal cancer. Our study showed that up-regulation of tumor necrosis factor receptor-associated protein 1 (TRAP1) occurred early in the neoplastic progression of UC associated cancer: it was present in both the dysplastic and non-dysplastic tissues of UC progressors. Our study further showed that the increase of TRAP1 expression in UC progressors positively correlated with the degree of inflammation in the colorectal cancer tissues, which could be related to the increased oxidation present in the colonic mucosa from UC progressors. TRAP1 could be a potential diagnostic marker for UC associated colorectal cancer.
Publish Date	2014-12-10 15:52
Citation	Chen R, Pan S, Lai K, Lai LA, Crispin DA, Bronner MP, Brentnall TA. Up-regulation of mitochondrial chaperone TRAP1 in ulcerative colitis associated colorectal cancer. World J Gastroenterol 2014; 20(45): 17037-17048
URL	http://www.wjgnet.com/1007-9327/full/v20/i45/17037.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i45.17037

Full Article (PDF)	WJG-20-17037.pdf
Full Article (Word)	WJG-20-17037.doc
Manuscript File	7693-Review.doc
Answering Reviewers	7693-Answering reviewers.pdf
Copyright License Agreement	7693-Copyright assignment.pdf
Peer-review Report	7693-Peer review.pdf
Scientific Editor Work List	7693-Scientific editor work list.doc