Publication Name	World Journal of Clinical Cases
Manuscript ID	77103
Country	China

Received	2022-04-15 09:43
Peer-Review Started	2022-04-15 09:44
To Make the First Decision
Return for Revision	2022-07-14 08:11
Revised	2022-09-14 12:15
Second Decision	2022-09-29 03:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-29 10:37
Articles in Press	2022-09-29 10:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-12 02:11
Publish the Manuscript Online	2022-10-27 04:55

ISSN	2307-8960 (online)
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	Novel compound heterozygous variants in the LHX3 gene caused combined pituitary hormone deficiency: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Shuang-Zhu Lin, Qi-Ji Ma, Qi-Ming Pang, Qian-Dui Chen, Wan-Qi Wang, Jia-Yi Li and Su-Li Zhang
ORCID	Author(s) ORCID Number Shuang-Zhu Lin http://orcid.org/0000-0001-5333-2138 Qi-Ji Ma http://orcid.org/0000-0001-9197-9733 Qi-Ming Pang http://orcid.org/0000-0002-9501-1700 Qian-Dui Chen http://orcid.org/0000-0002-8593-4077 Wan-Qi Wang http://orcid.org/0000-0002-8247-7616 Jia-Yi Li http://orcid.org/0000-0002-7729-4479 Su-Li Zhang http://orcid.org/0000-0001-5887-1026
Funding Agency and Grant Number
Corresponding Author	Su-Li Zhang, MD, Doctor, Doctor, Department of Neonatology, Hainan Women and Children's Medical Center, No. 15 Longkun Nan Road, Haikou 570100, Hainan Province, China. 18389454649@163.com
Key Words	Combined pituitary hormone deficiency; LHX3; Children; Gonadal dysplasia; Case report
Core Tip	We report an 11-yar-old boy with combined pituitary hormone deficiency (CPHD). DNA sequencing showed that there were two compound heterozygous variants in the LHX3 gene. This study extends the mutation spectrum of the LHX3 gene, and provides a molecular basis for the etiological diagnosis of CPHD and genetic consultation for the family.
Publish Date	2022-10-27 04:55
Citation	Lin SZ, Ma QJ, Pang QM, Chen QD, Wang WQ, Li JY, Zhang SL. Novel compound heterozygous variants in the LHX3 gene caused combined pituitary hormone deficiency: A case report. World J Clin Cases 2022; 10(31): 11486-11492
URL	https://www.wjgnet.com/2307-8960/full/v10/i31/11486.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i31.11486

Full Article (PDF)	WJCC-10-11486.pdf
Full Article (Word)	WJCC-10-11486.docx
CARE Checklist–2016	77103-CARE-Checklist–2016-revision.pdf
Manuscript File	77103_Auto_Edited-LJH-JLW.docx
Answering Reviewers	77103-Answering reviewers.pdf
Audio Core Tip	77103-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	77103-Conflict-of-interest statement.pdf
Copyright License Agreement	77103-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	77103-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	77103-Language certificate.pdf
Peer-review Report	77103-Peer-review(s).pdf
Scientific Misconduct Check	77103-Bing-Liu JH-2.jpg
Scientific Misconduct Check	77103-CrossCheck.jpg
Scientific Editor Work List	77103-Scientific editor work list.pdf
CrossCheck Report	77103-CrossCheck report.pdf