Publication Name	World Journal of Gastroenterology
Manuscript ID	7721
Country	China

Received	2013-11-29 13:53
Peer-Review Started	2013-11-29 23:35
To Make the First Decision	2013-12-26 11:12
Return for Revision	2013-12-26 17:20
Revised	2014-01-24 11:37
Second Decision	2014-03-19 13:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-19 15:25
Articles in Press	2014-05-23 11:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-16 10:16
Typeset the Manuscript	2014-08-22 12:56
Publish the Manuscript Online	2014-09-07 13:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis
Manuscript Source	Invited Manuscript
All Author List	Yu Wang, Li-Hua Huang, Can-Xia Xu, Jing Xiao, Li Zhou, Dan Cao, Xiao-Min Liu and Yong Qi
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81172301 Changsha Municipal Science and Technology Project K1106036-31
Corresponding Author	Can-Xia Xu, MD, Professor, Department of Gastroenterology, Third Xiangya Hospital of Central South University, 138 Tongzipo Street, Changsha 410013, Hunan Province, China. xucanxia2000@163.com
Key Words	Gastric cancer; Helicobacter pylori; Cx32; Cx43; DNA methylation
Core Tip	The relationship between Connexin (Cx) 32 and Cx43 mRNA expression and gene promoter methylation at different gastric carcinogenesis stages with H. pylori infection, that is, non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, dysplasia, and gastric cancer, is not clear. Here, gastric mucosa biopsy specimens from these carcinogenic stages, as well as normal gastric mucosa without H. pylori infection, were examined for Cx32 and Cx43 mRNA expression and promoter methylation by real-time polymerase chain reaction and methylation detection. Cx32 and Cx43 mRNA expression decreased gradually during gastric carcinogenesis, and it is associated with hypermethylation of these genes’ promoter.
Publish Date	2014-09-07 13:31
Citation	Wang Y, Huang LH, Xu CX, Xiao J, Zhou L, Cao D, Liu XM, Qi Y. Connexin 32 and 43 promoter methylation in Helicobacter pylori-associated gastric tumorigenesis. World J Gastroenterol 2014; 20(33): 11770-11779
URL	http://www.wjgnet.com/1007-9327/full/v20/i33/11770.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i33.11770

Full Article (PDF)	WJG-20-11770.pdf
Full Article (Word)	WJG-20-11770.doc
Manuscript File	7721-Review.doc
Answering Reviewers	7721-Answering reviewers.pdf
Copyright License Agreement	7721-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20131128152535.doc
Non-Native Speakers of English Editing Certificate	7721-Language certificate.PDF
Peer-review Report	7721-Peer review(s).pdf
Scientific Editor Work List	7721-Scientific editor work list.doc