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Articles Published Processes
9/9/2022 3:45:24 PM | Browse: 395 | Download: 697
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Received |
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2022-04-25 09:38 |
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Peer-Review Started |
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2022-04-25 09:39 |
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To Make the First Decision |
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Return for Revision |
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2022-05-30 00:02 |
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Revised |
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2022-06-13 17:55 |
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Second Decision |
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2022-08-15 06:43 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-16 16:17 |
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Articles in Press |
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2022-08-16 16:17 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-09-04 11:06 |
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Publish the Manuscript Online |
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2022-09-09 15:45 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Review |
| Article Title |
A review of potential mechanisms and uses of SGLT2 inhibitors in ischemia-reperfusion phenomena
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Victor Quentin, Manveer Singh and Lee S Nguyen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lee S Nguyen, MD, PhD, Doctor, Doctor, Senior Researcher, Research and Innovation, CMC Ambroise Paré, 25-27 Boulevard Victor Hugo, Neuilly-sur-Seine 92200, France. nguyen.lee@icloud.com |
| Key Words |
SGLT2 inhibitors; Ischemia-reperfusion injuries; Sodium-proton exchanger; Myocardial ischemia; Immunomodulation |
| Core Tip |
The antidiabetic drug-class sodium-glucose cotransporter-2 inhibitors (SGLT2i) showed efficacy in decreasing mortality in patients with chronic heart failure, in whom ischemia counts among the first cause. Remarkably, this benefit was observed independently from diabetic status. This feature, yielded from several randomized controlled trials, suggests additional effects from SGLT2i beyond isolated glycemia control. Indeed, previous in-vitro and animal models analyzed altogether suggests the role of the inhibition of the Na+/H+ exchanger, which holds a pivotal role in ischemia/reperfusion injuries. In this review, we aim to summarize evidence which associate SGLT2i and ischemia/reperfusion injuries, by first listing known mechanisms which portend the latter, and second, hypothesize how the former may interact with these mechanisms. |
| Publish Date |
2022-09-09 15:45 |
| Citation |
Quentin V, Singh M, Nguyen LS. A review of potential mechanisms and uses of SGLT2 inhibitors in ischemia-reperfusion phenomena. World J Diabetes 2022; 13(9): 683-695 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i9/683.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i9.683 |
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