| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Karim Atmani, Fabien Wuestenberghs, Maximilien Baron, Illona Bouleté, Charlène Guérin, Wafa Bahlouli, David Vaudry, Jean Claude do Rego, Jean-Nicolas Cornu, Anne-Marie Leroi, Moïse Coëffier, Mathieu Meleine and Guillaume Gourcerol |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guillaume Gourcerol, MD, PhD, Chief Doctor, Professor, Department of Physiology, CHU Rouen, Université de Rouen Normandie, 1 Rue de Germont, Rouen 76031, France. guillaume.gourcerol@chu-rouen.fr |
| Key Words |
Cross-organ sensitization; MAPK-p38; Microglia; NK1 receptor; Pain; Visceral hypersensitivity |
| Core Tip |
A model of chronic cross-organ visceral sensitization in mice was developed using ultrasound-guided intravesical injections of acetic acid. Visceral hypersensitivity to colorectal distension was observed as early as one hour post-injection and lasted up to seven days. Visceral hypersensitivity was associated with an increased expression of c-Fos protein in the spinal cord. NK1 receptor and MAPK-p38 levels were upregulated in the spinal cord seven days post-injection. Colorectal sensitization was prevented by intrathecal or intracerebroventricular (ICV) injections of minocycline, a microglia inhibitor, by ICV injection of CP-99994, a NK1 antagonist, and by ICV injection of SB203580, a MAPK-p38 inhibitor. |
| Publish Date |
2022-12-27 10:06 |
| Citation |
Atmani K, Wuestenberghs F, Baron M, Bouleté I, Guérin C, Bahlouli W, Vaudry D, do Rego JC, Cornu JN, Leroi AM, Coëffier M, Meleine M, Gourcerol G. Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice. World J Gastroenterol 2022; 28(48): 6935-6949 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i48/6935.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i48.6935 |
