Publication Name	World Journal of Gastroenterology
Manuscript ID	77340
Country	France

Received	2022-05-31 04:44
Peer-Review Started	2022-05-18 18:48
First Decision by Editorial Office Director	2022-08-01 18:33
Return for Revision	2022-08-01 18:33
Revised	2022-10-02 15:41
Publication Fee Transferred
Second Decision by Editor	2022-10-26 03:26
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-10-26 19:11
Articles in Press	2022-10-26 19:11
Edit the Manuscript by Language Editor	2022-11-03 22:43
Typeset the Manuscript	2022-12-21 03:29
Publish the Manuscript Online	2022-12-27 10:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Neurosciences
Manuscript Type	Basic Study
Article Title	Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice
Manuscript Source	Unsolicited Manuscript
All Author List	Karim Atmani, Fabien Wuestenberghs, Maximilien Baron, Illona Bouleté, Charlène Guérin, Wafa Bahlouli, David Vaudry, Jean Claude do Rego, Jean-Nicolas Cornu, Anne-Marie Leroi, Moïse Coëffier, Mathieu Meleine and Guillaume Gourcerol
ORCID	Author(s) ORCID Number Karim Atmani http://orcid.org/0000-0003-3584-0694 Fabien Wuestenberghs http://orcid.org/0000-0001-6100-6017 Maximilien Baron http://orcid.org/0000-0001-8496-9203 Illona Bouleté http://orcid.org/0000-0003-1697-5999 Charlène Guérin http://orcid.org/0000-0003-0585-8754 Wafa Bahlouli http://orcid.org/0000-0002-0049-240X David Vaudry http://orcid.org/0000-0003-3567-7452 Jean Claude do Rego http://orcid.org/0000-0001-5706-3780 Jean-Nicolas Cornu http://orcid.org/0000-0002-6735-1601 Anne-Marie Leroi http://orcid.org/0000-0002-6266-4203 Moïse Coëffier http://orcid.org/0000-0002-7469-2682 Mathieu Meleine http://orcid.org/0000-0002-0925-087X Guillaume Gourcerol http://orcid.org/0000-0001-8220-9155
Funding Agency and Grant Number
Corresponding Author	Guillaume Gourcerol, MD, PhD, Chief Doctor, Professor, Department of Physiology, CHU Rouen, Université de Rouen Normandie, 1 Rue de Germont, Rouen 76031, France. guillaume.gourcerol@chu-rouen.fr
Key Words	Cross-organ sensitization; MAPK-p38; Microglia; NK1 receptor; Pain; Visceral hypersensitivity
Core Tip	A model of chronic cross-organ visceral sensitization in mice was developed using ultrasound-guided intravesical injections of acetic acid. Visceral hypersensitivity to colorectal distension was observed as early as one hour post-injection and lasted up to seven days. Visceral hypersensitivity was associated with an increased expression of c-Fos protein in the spinal cord. NK1 receptor and MAPK-p38 levels were upregulated in the spinal cord seven days post-injection. Colorectal sensitization was prevented by intrathecal or intracerebroventricular (ICV) injections of minocycline, a microglia inhibitor, by ICV injection of CP-99994, a NK1 antagonist, and by ICV injection of SB203580, a MAPK-p38 inhibitor.
Publish Date	2022-12-27 10:06
Citation	Atmani K, Wuestenberghs F, Baron M, Bouleté I, Guérin C, Bahlouli W, Vaudry D, do Rego JC, Cornu JN, Leroi AM, Coëffier M, Meleine M, Gourcerol G. Bladder-colon chronic cross-sensitization involves neuro-glial pathways in male mice. World J Gastroenterol 2022; 28(48): 6935-6949
URL	https://www.wjgnet.com/1007-9327/full/v28/i48/6935.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i48.6935

Full Article (PDF)	WJG-28-6935.pdf
Full Article (Word)	WJG-28-6935.docx
The ARRIVE Guidelines	77340-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	77340-Review-FilipodiaCL.docx
Answering Reviewers	77340-Answering reviewers.pdf
Audio Core Tip	77340-Audio core tip.m4a
Biostatistics Review Certificate	77340-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	77340-Conflict-of-interest statement.pdf
Copyright License Agreement	77340-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	77340-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	77340-Language certificate.pdf
Supplementary Material	77340-Supplementary material.pdf
Peer-review Report	77340-Peer-review(s).pdf
Scientific Editor Work List	77340-Scientific editor work list.pdf
CrossCheck Report	77340-CrossCheck report.pdf