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Articles Published Processes
9/9/2022 3:45:24 PM | Browse: 404 | Download: 1033
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Received |
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2022-04-29 02:18 |
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Peer-Review Started |
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2022-04-29 02:21 |
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To Make the First Decision |
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Return for Revision |
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2022-05-29 23:48 |
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Revised |
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2022-06-09 10:05 |
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Second Decision |
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2022-08-25 03:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-25 21:13 |
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Articles in Press |
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2022-08-25 21:13 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-09-01 14:15 |
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Publish the Manuscript Online |
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2022-09-09 15:45 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Basic Study |
| Article Title |
Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bing-Wei Li, Yuan Li, Xu Zhang, Sun-Jing Fu, Bing Wang, Xiao-Yan Zhang, Xue-Ting Liu, Qin Wang, Ai-Ling Li and Ming-Ming Liu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming-Ming Liu, PhD, Research Scientist, Institute of Microcirculation, Diabetes Research Center, Chinese Academy of Medical Sciences & Peking Union Medical College, No.5 Dong Dan Third Alley, Dongcheng District, Beijing 100005, China. mingmingliu@imc.pumc.edu.cn |
| Key Words |
Diabetes mellitus; Glucotoxicity; Endothelial cells; Microcirculation; Mitochondria; Bioenergetics |
| Core Tip |
The pancreatic islet microvasculature adapts its metabolism to cope with limited oxygen availability and nutrient delivery. Insulin has been proven to exert complex actions promoting the maintenance of homeostasis under glucotoxicity. Our findings demonstrate that insulin ameliorates the suppression of the integrated microcirculatory oxygen profile in type 1 diabetes mellitus mice and improves mitochondrial ultrastructural abnormalities in islet microvascular endothelial cells (IMECs). Additionally, insulin administration restores glucotoxicity-induced microcirculatory failure by increasing the mitochondrial basal respiration and glycolytic capacity of IMECs. |
| Publish Date |
2022-09-09 15:45 |
| Citation |
Li BW, Li Y, Zhang X, Fu SJ, Wang B, Zhang XY, Liu XT, Wang Q, Li AL, Liu MM. Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics. World J Diabetes 2022; 13(9): 765-775 |
| URL |
https://www.wjgnet.com/1948-9358/full/v13/i9/765.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v13.i9.765 |
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