Publication Name	World Journal of Gastroenterology
Manuscript ID	7752
Country	Austria

Received	2013-11-30 13:01
Peer-Review Started	2013-12-02 16:54
To Make the First Decision	2014-01-09 18:35
Return for Revision	2014-01-20 21:54
Revised	2014-02-07 20:08
Second Decision	2014-03-13 16:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-13 16:30
Articles in Press	2014-05-23 11:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-21 17:30
Typeset the Manuscript	2014-06-13 13:59
Publish the Manuscript Online	2014-06-27 10:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Epigenetics and pancreatic cancer: Pathophysiology and novel treatment aspects
Manuscript Source	Invited Manuscript
All Author List	Daniel Neureiter, Tarkan Jäger, Matthias Ocker and Tobias Kiesslich
Funding Agency and Grant Number
Corresponding Author	Daniel Neureiter, MD, MA, Institute of Pathology, Paracelsus Medical University/Salzburger Landeskliniken (SALK), Muellner Hauptstrasse 48, 5020 Salzburg, Austria. d.neureiter@salk.at
Key Words	Pancreatic cancer; Epigenetics; DNA methylation; Histone modification; microRNA; Targeted therapy; Epithelial-mesenchymal transition
Core Tip	Pancreatic cancer represents a devastating disease with poor overall survival at advanced stages, and new and effective treatment options are required. Besides genetic mutations, epigenetic dysregulation of oncogenes and tumor suppressor genes is recognized as a novel therapeutic target. Mechanisms underlying DNA methylation, histone acetylation and microRNA regulation and their contribution to pancreatic cancer development and resistance to treatment are highlighted in this review. Potential therapeutic interventions are discussed.
Publish Date	2014-06-27 10:37
Citation	Neureiter D, Jäger T, Ocker M, Kiesslich T. Epigenetics and pancreatic cancer: Pathophysiology and novel treatment aspects. World J Gastroenterol 2014; 20(24): 7830-7848
URL	http://www.wjgnet.com/1007-9327/full/v20/i24/7830.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i24.7830

Full Article (PDF)	WJG-20-7830.pdf
Full Article (Word)	WJG-20-7830.doc
Manuscript File	7752-Review.docx
Answering Reviewers	7752-Answering reviewers.pdf
Copyright License Agreement	7752-Copyright assignment.pdf
Peer-review Report	7752-Peer review(s).pdf
Scientific Editor Work List	7752-Scientific editor work list.doc