Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	77566
Country	China

Received	2022-05-07 03:47
Peer-Review Started	2022-05-07 03:50
To Make the First Decision
Return for Revision	2022-07-13 23:04
Revised	2022-07-23 17:15
Second Decision	2022-09-02 03:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-07 23:38
Articles in Press	2022-09-07 23:38
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-08-31 08:05
Typeset the Manuscript	2022-10-08 04:56
Publish the Manuscript Online	2022-10-14 12:54

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Transcriptional factor III A promotes colorectal cancer progression by upregulating cystatin A
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Wang, Yuan Tan, Qun-Ying Jia and Fa-Qin Tang
ORCID	Author(s) ORCID Number Jing Wang http://orcid.org/0000-0002-6594-3494 Yuan Tan http://orcid.org/0000-0003-0362-4073 Qun-Ying Jia http://orcid.org/0000-0003-4660-3790 Fa-Qin Tang http://orcid.org/0000-0001-5794-4975
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81872226 Changsha Science and Technology Project 2019TP1046 Research Projects of Hunan Health Commission B2019084
Corresponding Author	Fa-Qin Tang, MD, PhD, Doctor, Doctor, Professor, Hunan Key Laboratory of Oncotarget Gene, Hunan Cancer Hospital & The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, No. 283 Tongzipo Road, Changsha 410013, Hunan Province, China. tangfq@hnca.org.cn
Key Words	Transcription factor IIIA; Cystatin A; Colorectal cancer; Epithelial-mesenchymal transition
Core Tip	Transcriptional factor III A (GTF3A) is highly expressed in colorectal cancer (CRC) tissues, and GTF3A expression is associated with CRC prognosis. GTF3A binds to the promoter of cystatin (Csta) gene to facilitate Csta transcription, which regulates the expression of epithelial-mesenchymal transition markers and promotes CRC progression. Blocking GTF3A significantly inhibits CRC cell growth. Therefore, GTF3A is a potential novel therapeutic target and prognostic biomarker for CRC.
Publish Date	2022-10-14 12:54
Citation	Wang J, Tan Y, Jia QY, Tang FQ. Transcriptional factor III A promotes colorectal cancer progression by upregulating cystatin A. World J Gastrointest Oncol 2022; 14(10): 1918-1932
URL	https://www.wjgnet.com/1948-5204/full/v14/i10/1918.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i10.1918

Full Article (PDF)	WJGO-14-1918.pdf
Full Article (Word)	WJGO-14-1918.docx
The ARRIVE Guidelines	77566-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	77566_Auto_Edited-JJW-WangTQ-LS.docx
Answering Reviewers	77566-Answering reviewers.pdf
Audio Core Tip	77566-Audio core tip.m4a
Biostatistics Review Certificate	77566-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	77566-Conflict-of-interest statement.pdf
Copyright License Agreement	77566-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77566-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	77566-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	77566-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	77566-Language certificate.pdf
Supplementary Material	77566-Supplementary material.pdf
Peer-review Report	77566-Peer-review(s).pdf
Scientific Misconduct Check	77566-Bing-Wang JJ-2.png
Scientific Editor Work List	77566-Scientific editor work list.pdf
CrossCheck Report	77566-CrossCheck report.pdf