Publication Name	World Journal of Gastroenterology
Manuscript ID	7758
Country	Germany

Received	2013-11-30 13:14
Peer-Review Started	2013-12-02 14:20
To Make the First Decision	2014-01-09 18:36
Return for Revision	2014-01-20 21:54
Revised	2014-02-17 03:13
Second Decision	2014-04-23 09:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-23 09:55
Articles in Press	2014-05-23 11:01
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-26 16:01
Typeset the Manuscript	2014-07-10 11:19
Publish the Manuscript Online	2014-07-26 13:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications
Manuscript Source	Invited Manuscript
All Author List	Inaam A Nakchbandi
Funding Agency and Grant Number
Corresponding Author	Inaam Nakchbandi, MD, FACP, Professor of Medicine, Translational Medicine, University of Heidelberg, Im Neuenheimer Feld 305, 2. OG, R210, 69120 Heidelberg, Germany. inaam.nakchbandi@immu.uni-heidelberg.de
Key Words	Osteoporosis; Liver disease; Fracture; Prevalence; Pathogenesis; Fibronectin; Insulin like growth factor-Ⅰ; Therapy; Vitamin D; Calcium
Core Tip	Up to 40% of patients with chronic liver disease may experience a fracture. The pathogenic mediators include fibronectin, insulin like growth factor-Ⅰ, and various cytokines. Decreased vitamin D and/or treatment with corticosteroids contribute to worsening bone health. Treatment should include calcium and vitamin D supplementation in all patients with chronic liver disease. Therapy with bisphosphonates should be considered, especially in patients receiving corticosteroids.
Publish Date	2014-07-26 13:36
Citation	Nakchbandi IA. Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications. World J Gastroenterol 2014; 20(28): 9427-9438
URL	http://www.wjgnet.com/1007-9327/full/v20/i28/9427.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i28.9427

Full Article (PDF)	WJG-20-9427.pdf
Full Article (Word)	WJG-20-9427.doc
Manuscript File	7758-Review.docx
Answering Reviewers	7758-Answering reviewers.pdf
Copyright License Agreement	7758-Copyright assignment.pdf
Peer-review Report	7758-Peer review(s).pdf
Scientific Editor Work List	7758-Scientific editor work list.doc