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8/25/2014 4:06:00 PM | Browse: 926 | Download: 865
Publication Name World Journal of Gastroenterology
Manuscript ID 7758
Country/Territory Germany
Received
2013-11-30 13:14
Peer-Review Started
2013-12-02 14:20
To Make the First Decision
2014-01-09 18:36
Return for Revision
2014-01-20 21:54
Revised
2014-02-17 03:13
Second Decision
2014-04-23 09:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-04-23 09:55
Articles in Press
2014-05-23 11:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-04-26 16:01
Typeset the Manuscript
2014-07-10 11:19
Publish the Manuscript Online
2014-07-26 13:36
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Review
Article Title Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications
Manuscript Source Invited Manuscript
All Author List Inaam A Nakchbandi
Funding Agency and Grant Number
Corresponding Author Inaam Nakchbandi, MD, FACP, Professor of Medicine, Translational Medicine, University of Heidelberg, Im Neuenheimer Feld 305, 2. OG, R210, 69120 Heidelberg, Germany. inaam.nakchbandi@immu.uni-heidelberg.de
Key Words Osteoporosis; Liver disease; Fracture; Prevalence; Pathogenesis; Fibronectin; Insulin like growth factor-Ⅰ; Therapy; Vitamin D; Calcium
Core Tip Up to 40% of patients with chronic liver disease may experience a fracture. The pathogenic mediators include fibronectin, insulin like growth factor-Ⅰ, and various cytokines. Decreased vitamin D and/or treatment with corticosteroids contribute to worsening bone health. Treatment should include calcium and vitamin D supplementation in all patients with chronic liver disease. Therapy with bisphosphonates should be considered, especially in patients receiving corticosteroids.
Publish Date 2014-07-26 13:36
Citation Nakchbandi IA. Osteoporosis and fractures in liver disease: Relevance, pathogenesis and therapeutic implications. World J Gastroenterol 2014; 20(28): 9427-9438
URL http://www.wjgnet.com/1007-9327/full/v20/i28/9427.htm
DOI http://dx.doi.org/10.3748/wjg.v20.i28.9427
Full Article (PDF) WJG-20-9427.pdf
Full Article (Word) WJG-20-9427.doc
Manuscript File 7758-Review.docx
Answering Reviewers 7758-Answering reviewers.pdf
Copyright License Agreement 7758-Copyright assignment.pdf
Peer-review Report 7758-Peer review(s).pdf
Scientific Editor Work List 7758-Scientific editor work list.doc