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Articles Published Processes
9/23/2022 10:13:16 AM | Browse: 453 | Download: 1423
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Received |
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2022-05-11 14:24 |
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Peer-Review Started |
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2022-05-11 14:25 |
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To Make the First Decision |
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Return for Revision |
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2022-08-01 19:37 |
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Revised |
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2022-08-11 15:12 |
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Second Decision |
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2022-09-06 03:20 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-09-07 22:33 |
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Articles in Press |
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2022-09-07 22:33 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-09-15 02:17 |
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Publish the Manuscript Online |
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2022-09-23 10:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection: A 15-year observational study
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jae Hyun Yoon, Sung Kyu Choi, Sung Bum Cho, Hee Joon Kim, Yang Seok Ko and Chung Hwan Jun |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research Supporting Program of the Korean Association for the Study of the Liver and the Korean Liver Foundation |
KASLKLF2019-06 |
| Chonnam National University Hospital Biomedical Research Institute |
BCRI121007 |
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| Corresponding Author |
Sung Kyu Choi, MD, PhD, Professor, Department of Gastroenterology and Hepatology, Chonnam National University Hospital and College of Medicine, Jebongroe 42, Gwangju 61469, South Korea. choisk@jnu.ac.kr |
| Key Words |
Early extrahepatic recurrence; Hepatocellular carcinoma; Prognosis; Surgery; Survival |
| Core Tip |
Surgical resection of hepatocellular carcinoma is effective and curative treatment modality. However, early extrahepatic recurrence (EHR) after resection is related to poor prognosis. This study indicates the close correlation between the early EHR and survival outcome (hazard ratio 6.77, 95% confidence interval 4.81-9.52). The time to EHR was 8.8 mo and in 52.7% of early EHR group, EHR occurred as the first recurrence. On multivariate analysis, serum albumin < 4.0 g/dL, serum alkaline phosphatase > 100 U/L, surgical margin involvement, venous and/or lymphatic involvement, satellite nodules, tumor necrosis, tumor size ≥ 7 cm, and macrovascular invasion were associated risk factors with early EHR. |
| Publish Date |
2022-09-23 10:13 |
| Citation |
Yoon JH, Choi SK, Cho SB, Kim HJ, Ko YS, Jun CH. Early extrahepatic recurrence as a pivotal factor for survival after hepatocellular carcinoma resection: A 15-year observational study. World J Gastroenterol 2022; 28(36): 5351-5363 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i36/5351.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i36.5351 |
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