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Articles Published Processes
10/28/2022 12:37:03 PM | Browse: 364 | Download: 749
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Received |
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2022-05-10 13:19 |
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Peer-Review Started |
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2022-05-10 13:21 |
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To Make the First Decision |
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Return for Revision |
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2022-08-20 01:08 |
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Revised |
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2022-09-08 10:50 |
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Second Decision |
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2022-10-10 03:28 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-10-10 14:52 |
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Articles in Press |
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2022-10-10 14:52 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-10-12 02:56 |
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Publish the Manuscript Online |
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2022-10-28 12:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Heterogeneity of immune control in chronic hepatitis B virus infection: Clinical implications on immunity with interferon-α treatment and retreatment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Guo-Qing Yin, Ke-Ping Chen and Xiao-Chun Gu |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Guo-Qing Yin, MD, PhD, Chief Doctor, Chief Physician, Center of Hepatology, Zhong-Da Hospital, Southeast University, No. 87 Dingjiaqiao, Nanjing 210009 , Jiangsu Province, China. yingq62@sina.com |
| Key Words |
Hepatitis B virus; Chronic; Functional cure; Heterogeneity; Immunity; Immune control; Interferon-α; Retreatment |
| Core Tip |
Hepatitis B virus (HBV)-specific immune control is characterized by distinct phenotypical and functional profiles. Owing to the negative feedback associated with all immune responses in an infected host, immunomodulators regulating a single immune pathway are unlikely to fully restore antiviral immunity. Interferon-α (IFN-α) treatment was shown to simultaneously affect multiple immune pathways and various immune cell populations in the host and integrate signals toward improving HBV-specific immune control. In addition, IFN-α retreatment was shown to improved functional cure rates, indicating that could gradually enhance the overall immune control. |
| Publish Date |
2022-10-28 12:37 |
| Citation |
Yin GQ, Chen KP, Gu XC. Heterogeneity of immune control in chronic hepatitis B virus infection: Clinical implications on immunity with interferon-α treatment and retreatment. World J Gastroenterol 2022; 28(40): 5784-5800 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i40/5784.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i40.5784 |
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