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        9/15/2022 1:37:25 PM | Browse: 533 | Download: 1973
    
    
        
        
    
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                    |  | Received |  | 2022-05-25 14:20 | 
    
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                    |  | Peer-Review Started |  | 2022-05-25 14:23 | 
    
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                    |  | To Make the First Decision |  |  | 
    
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                    |  | Return for Revision |  | 2022-07-12 23:58 | 
    
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                    |  | Revised |  | 2022-07-23 16:35 | 
    
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                    |  | Second Decision |  | 2022-08-18 03:10 | 
    
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                    |  | Accepted by Journal Editor-in-Chief |  |  | 
    
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                    |  | Accepted by Executive Editor-in-Chief |  | 2022-08-22 16:35 | 
    
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                    |  | Articles in Press |  | 2022-08-22 16:35 | 
    
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                    |  | Publication Fee Transferred |  |  | 
    
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                    |  | Edit the Manuscript by Language Editor |  |  | 
    
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                    |  | Typeset the Manuscript |  | 2022-09-06 10:44 | 
            
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                            |  | Publish the Manuscript Online |  | 2022-09-15 13:37 | 
        
        
            
                | ISSN | 1007-9327 (print) and 2219-2840 (online) | 
            
                | Open Access | This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ | 
            
                | Copyright | ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. | 
                    
                        | Article Reprints | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247 | 
            
            
                | Permissions | For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207 | 
            
            
                | Publisher | Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA | 
            
                | Website | http://www.wjgnet.com | 
        
    
        | Category | Oncology | 
    
        | Manuscript Type | Basic Study | 
    
        | Article Title | Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin-γ2 and integrin-β1 | 
    
        | Manuscript Source | Unsolicited Manuscript | 
    
        | All Author List | Fei-Fei Nong, Yu-Qi Liang, Shang-Ping Xing, Yin-Fang Xiao, Hui-Hui Chen and Bin Wen | 
            
                | ORCID |  | 
    
        | Funding Agency and Grant Number | 
                        
                            
                                | Funding Agency | Grant Number |  
                                        | National Natural Science Foundation of China | 81673944 |  | 
    
        | Corresponding Author | Bin Wen, PhD, Academic Research, Full Professor, Pi‐Wei Institute, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, No. 232 Waihuandong Road, Guangzhou 510000, Guangdong Province, China. wenbin@gzucm.edu.cn | 
    
        | Key Words | Alcohol; Colorectal cancer; Premetastatic niche; Epithelial mesenchymal transformation; Metastasis | 
    
        | Core Tip | Our study indicated that alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer (CRC) by activating the early interaction between laminin γ2 and integrin β1 and lead to CRC metastasis. | 
            
                | Publish Date | 2022-09-15 13:37 | 
    
        | Citation | Nong FF, Liang YQ, Xing SP, Xiao YF, Chen HH, Wen B. Alcohol promotes epithelial mesenchymal transformation-mediated premetastatic niche formation of colorectal cancer by activating interaction between laminin γ2 and integrin β1. World J Gastroenterol 2022; 28(35): 5154-5174 | 
            
                | URL | https://www.wjgnet.com/1007-9327/full/v28/i35/5154.htm | 
            
                | DOI | https://dx.doi.org/10.3748/wjg.v28.i35.5154 | 
    
    
        
                
        
     
 
                 
             
         
        
    
        
        
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