Publication Name	World Journal of Biological Chemistry
Manuscript ID	7770
Country	United States

Received	2013-11-30 14:02
Peer-Review Started	2013-12-02 10:22
To Make the First Decision	2013-12-13 13:35
Return for Revision	2013-12-17 16:42
Revised	2014-01-11 09:32
Second Decision	2014-03-14 18:21
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-14 18:35
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-05-19 12:09
Publish the Manuscript Online	2014-06-11 10:30

ISSN	1949-8454 (online)
Open Access
Copyright
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Category	Biochemistry & Molecular Biology
Manuscript Type	Review
Article Title	Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1
Manuscript Source	Invited Manuscript
All Author List	Xiao-Xin Sun and Mu-Shui Dai
Funding Agency and Grant Number	Funding Agency Grant Number NIH R00 CA127134 NCI R01 CA160474 Department of Defense W81XWH-10-1-1029 (to Dai MS) Medical Research Foundation (MRF) of Oregon to Sun XX
Corresponding Author	Mu-Shui Dai, MD, PhD, Department of Molecular and Medical Genetics, School of Medicine, and the OHSU Knight Cancer Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, United States. daim@ohsu.edu
Key Words	p53; MDM2; Ubiquitination; Deubiquitinating enzymes; Otub1; Cell cycle; Apoptosis
Core Tip	p53 is tightly regulated by dynamic ubiquitination and deubiquitination. A number of deubiquitinating enzymes (DUBs) have been shown to regulate p53 stability and activity by either directly deubiquitinating p53 or indirectly deubiquitinating its regulators. We recently discovered that Otub1, an OTU family DUB, stabilizes and activates p53 via distinct and non-canonical mechanism wherein it suppresses the MDM2 cognate ubiquitin-conjugating enzymes UbcH5. Here we review the current progress made towards the understanding of the Otub1 functions as a potent E2 inhibitor and the underlying mechanisms.
Publish Date	2014-06-11 10:30
Citation	Sun XX, Dai MS. Deubiquitinating enzyme regulation of the p53 pathway: A lesson from Otub1. World J Biol Chem 2014; 5(2): 75-84
URL	http://www.wjgnet.com/1949-8454/full/v5/i2/75.htm
DOI	http://dx.doi.org/10.4331/wjbc.v5.i2.75

Full Article (PDF)	wjbc-5-75.pdf
Full Article (Word)	wjbc-5-75.doc
Manuscript File	7770-Review.docx
Answering Reviewers	7770-Answering reviewers.pdf
Copyright License Agreement	7770-Copyright assignment.pdf
Peer-review Report	7770-Peer review(s).pdf
Scientific Editor Work List	7770-Scientific editor work list.doc