Publication Name	World Journal of Stem Cells
Manuscript ID	77709
Country	China

Received	2022-05-18 09:12
Peer-Review Started	2022-05-18 09:15
To Make the First Decision
Return for Revision	2022-06-23 16:07
Revised	2022-07-07 02:59
Second Decision	2022-09-02 03:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-09-07 23:51
Articles in Press	2022-09-07 23:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-09-22 00:32
Publish the Manuscript Online	2022-09-23 09:45

ISSN	1948-0210 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Cell Biology
Manuscript Type	Review
Article Title	Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease
Manuscript Source	Unsolicited Manuscript
All Author List	Meng-Yue Shi, Lian Liu and Fu-Yuan Yang
ORCID	Author(s) ORCID Number Meng-Yue Shi http://orcid.org/0000-0002-3890-8335 Fu-Yuan Yang http://orcid.org/0000-0001-9179-195X
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Research Project of Hubei Province 2021CFB210
Corresponding Author	Fu-Yuan Yang, PhD, Lecturer, Health Science Center, Yangtze University, No. 1 Xueyuan Road, Jingzhou 434020, Hubei Province, China. ivansblue@sina.com
Key Words	Mesenchymal stem cells; Inflammatory bowel diseases; Inflammation; Pretreatment; Gene editing
Core Tip	Mesenchymal stem cell (MSC) transplantation is a novel treatment method for inflammatory bowel disease (IBD) that has exhibits certain achievements in clinical trials. Here, we reviewed the developed strategies for enhancing the therapeutic effect of MSCs, and among these, pretreatment with MSCs is the most common method. The pretreatments include bioactive substances, hypoxia and modification of culture methods and are able to enhance the migration ability of MSCs to repair the damaged intestinal mucosa or upregulate the expression of cytokines. These methods provide new ideas for the future clinical application of MSCs in the treatment of IBD.
Publish Date	2022-09-23 09:45
Citation	Shi MY, Liu L, Yang FY. Strategies to improve the effect of mesenchymal stem cell therapy on inflammatory bowel disease. World J Stem Cells 2022; 14(9): 684-699
URL	https://www.wjgnet.com/1948-0210/full/v14/i9/684.htm
DOI	https://dx.doi.org/10.4252/wjsc.v14.i9.684

Full Article (PDF)	WJSC-14-684.pdf
Full Article (Word)	WJSC-14-684.docx
Manuscript File	77709_Auto_Edited-LS.docx
Answering Reviewers	77709-Answering reviewers.pdf
Audio Core Tip	77709-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	77709-Conflict-of-interest statement.pdf
Copyright License Agreement	77709-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77709-Grant application form(s).pdf
Non-Native Speakers of English Editing Certificate	77709-Language certificate.pdf
Peer-review Report	77709-Peer-review(s).pdf
Scientific Misconduct Check	77709-Bing-Wang JJ-2.png
Scientific Editor Work List	77709-Scientific editor work list.pdf
CrossCheck Report	77709-CrossCheck report.pdf