Publication Name	World Journal of Clinical Cases
Manuscript ID	77719
Country	China

Received	2022-05-17 02:42
Peer-Review Started	2022-05-17 02:44
To Make the First Decision
Return for Revision	2022-06-16 08:11
Revised	2022-06-24 15:59
Second Decision	2022-08-19 03:10
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-21 17:54
Articles in Press	2022-08-21 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-08-14 11:01
Typeset the Manuscript	2022-09-02 06:28
Publish the Manuscript Online	2022-09-16 11:52

ISSN	2307-8960 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	You-Lin Shao, Chun-Ming Ma, Jian-Ming Wu, Feng-Cai Guo and Suo-Cai Zhang
ORCID	Author(s) ORCID Number You-Lin Shao http://orcid.org/0000-0002-5054-7456 Chun-Ming Ma http://orcid.org/0000-0002-9777-981X Jian-Ming Wu http://orcid.org/0000-0002-3466-0926 Feng-Cai Guo http://orcid.org/0000-0002-7949-2137 Suo-Cai Zhang http://orcid.org/0000-0003-3605-8768
Funding Agency and Grant Number	Funding Agency Grant Number Applied Basic Research Project of Changzhou CJ20190080
Corresponding Author	You-Lin Shao, MD, Chief Physician, Department of Hepatology, Changzhou Third People's Hospital, No. 300 North Lanling Road, Changzhou 213001, Jiangsu Province, China. syl84289@aliyun.com
Key Words	Polygonum multiflorum; Hepatotoxicity; Agranulocytosis; Case report
Core Tip	Polygonum multiflorum is a common traditional Chinese medicine and is commonly used as a dietary supplement. However, severe idiosyncratic hepatotoxicity in certain individuals has been reported. Moreover, if idiosyncratic agranulocytosis occurs simultaneously, it may be fatal. Roussel Uclaf Causality Assessment Method scale and Naranjo algorithm are useful tools for the assessment of drug-induced liver injury and adverse drug reactions, respectively. Early discontinuation can prevent disease progression, facilitating recovery. The combination therapy of glucocorticoids, anti-inflammatory medications, and liver protection is beneficial for idiosyncratic drug reactions.
Publish Date	2022-09-16 11:52
Citation	Shao YL, Ma CM, Wu JM, Guo FC, Zhang SC. Concurrent severe hepatotoxicity and agranulocytosis induced by Polygonum multiflorum: A case report. World J Clin Cases 2022; 10(27): 9921-9928
URL	https://www.wjgnet.com/2307-8960/full/v10/i27/9921.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i27.9921

Full Article (PDF)	WJCC-10-9921.pdf
Full Article (Word)	WJCC-10-9921.docx
CARE Checklist–2016	77719-CARE-Checklist–2016-revision.pdf
Manuscript File	77719_Auto_Edited-JRF-Wang TQ-LS.docx
Answering Reviewers	77719-Answering reviewers.pdf
Audio Core Tip	77719-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	77719-Conflict-of-interest statement.pdf
Copyright License Agreement	77719-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77719-Grant application form(s).pdf
Signed Consent for Treatment Form(s) or Document(s)	77719-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	77719-Language certificate.pdf
Peer-review Report	77719-Peer-review(s).pdf
Scientific Misconduct Check	77719-Bing-Fan JR-2.png
Scientific Editor Work List	77719-Scientific editor work list.pdf