| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Effects of COVID-19 on the liver: The experience of a single center
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Valentina Liakina, Ieva Stundiene, Gabriele Milaknyte, Ramune Bytautiene, Rosita Reivytyte, Roma Puronaite, Gintare Urbanoviciute and Edita Kazenaite |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Valentina Liakina, PhD, Senior Research Fellow, Centre of Hepatology, Gastroenterology and Dietetics, Clinic of Gastroenterology, Nephrourology and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, 3 Universiteto Street, Vilnius 01513, Lithuania. valentina.liakina@santa.lt |
| Key Words |
COVID-19; SARS-CoV-2; Liver enzymes; Complications; Underlying disease; Disease severity |
| Core Tip |
In our study, elevated liver enzymes were detected in 88.2% of patients hospitalized with coronavirus disease 2019 (COVID-19). Alanine aminotransferase and aspartate aminotransferase were elevated by a factor of less than 3 in 54.9% and 74.8% of cases, respectively. Regardless of underlying diseases, including hepatitis, these patients had higher biochemical indices of inflammation, required an O2 supply, and exhibited bacterial pneumonia complications more often than those with normal liver tests. Male gender, older age, diabetes, and hyperlipidemia were confirmed as independent factors associated with a more severe course of COVID-19. All deceased patients (2.9%) had underlying diseases — most often heart disease, hypertension, and urinary tract infections. |
| Publish Date |
2022-10-18 08:29 |
| Citation |
Liakina V, Stundiene I, Milaknyte G, Bytautiene R, Reivytyte R, Puronaite R, Urbanoviciute G, Kazenaite E. Effects of COVID-19 on the liver: The experience of a single center . World J Gastroenterol 2022; 28(39): 5735-5749 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i39/5735.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i39.5735 |
