Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	77770
Country	China

Received	2022-05-30 14:53
Peer-Review Started	2022-05-30 14:56
To Make the First Decision
Return for Revision	2022-06-21 13:46
Revised	2022-07-04 23:07
Second Decision	2022-08-19 03:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-08-21 18:04
Articles in Press	2022-08-21 18:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-10-08 05:07
Publish the Manuscript Online	2022-10-14 12:54

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Interleukin-34 promotes the proliferation and epithelial-mesenchymal transition of gastric cancer cells
Manuscript Source	Unsolicited Manuscript
All Author List	Chuan-Hong Li, Zhang-Ming Chen, Pei-Feng Chen, Lei Meng, Wan-Nian Sui, Song-Cheng Ying, A-Man Xu and Wen-Xiu Han
ORCID	Author(s) ORCID Number Chuan-Hong Li http://orcid.org/0000-0002-3945-972X Zhang-Ming Chen http://orcid.org/0000-0002-4830-0745 Pei-Feng Chen http://orcid.org/0000-0003-2843-425X Lei Meng http://orcid.org/0000-0002-1089-1228 Wan-Nian Sui http://orcid.org/0000-0002-4337-5238 Song-Cheng Ying http://orcid.org/0000-0002-3446-4482 A-Man Xu http://orcid.org/0000-0002-7171-5295 Wen-Xiu Han http://orcid.org/0000-0002-5335-9645
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Project of Anhui Province KJ2021ZD0022 Key Research and Development Program of Anhui Province 202104J07020029
Corresponding Author	Wen-Xiu Han, MD, PhD, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Avenue, Shushan District, Hefei 230022, Anhui Province, China. hwxhbh@126.com
Key Words	Gastric cancer; Interleukin-34; Proliferation; Epithelial-mesenchymal transition; Metastasis
Core Tip	Our study provides novel evidence that interleukin (IL)-34 contribute the growth and metastasis of gastric cancer (GC). IL-34 is up-regulated in GC cell lines and tissues, which is correlated with tumor size, grade of differentiation and tumor, node and metastasis stage. IL-34 enhances the ability of proliferation, clone formation, migration and invasion of GC cells and regulates the expression levels of epithelial-mesenchymal transition-associated proteins, suggesting that IL-34 may be an effective target for the therapy of GC.
Publish Date	2022-10-14 12:54
Citation	Li CH, Chen ZM, Chen PF, Meng L, Sui WN, Ying SC, Xu AM, Han WX. Interleukin-34 promotes the proliferation and epithelial-mesenchymal transition of gastric cancer cells. World J Gastrointest Oncol 2022; 14(10): 1968-1980
URL	https://www.wjgnet.com/1948-5204/full/v14/i10/1968.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i10.1968

Full Article (PDF)	WJGO-14-1968.pdf
Full Article (Word)	WJGO-14-1968.docx
The ARRIVE Guidelines	77770-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	77770_Auto_Edited-LS.docx
Answering Reviewers	77770-Answering reviewers.pdf
Audio Core Tip	77770-Audio core tip.m4a
Biostatistics Review Certificate	77770-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	77770-Conflict-of-interest statement.pdf
Copyright License Agreement	77770-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	77770-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document	77770-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	77770-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	77770-Language certificate.pdf
Peer-review Report	77770-Peer-review(s).pdf
Scientific Editor Work List	77770-Scientific editor work list.pdf
CrossCheck Report	77770-CrossCheck report.pdf