Publication Name	World Journal of Clinical Cases
Manuscript ID	77911
Country	China

Received	2022-05-31 06:06
Peer-Review Started	2022-05-31 06:07
To Make the First Decision
Return for Revision	2022-06-27 09:09
Revised	2022-07-09 08:34
Second Decision	2022-08-23 03:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-08-23 16:40
Articles in Press	2022-08-23 16:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-08-31 01:43
Publish the Manuscript Online	2022-09-29 09:17

ISSN	2307-8960 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Dermatology
Manuscript Type	Case Report
Article Title	Cutaneous allergic reaction to subcutaneous vitamin K1: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Miao Zhang, Jia Chen, Chun-Xiao Wang, Nai-Xuan Lin and Xin Li
ORCID	Author(s) ORCID Number Miao Zhang http://orcid.org/0000-0002-0340-2043 Jia Chen http://orcid.org/0000-0002-7094-9460 Chun-Xiao Wang http://orcid.org/0000-0002-5233-9079 Nai-Xuan Lin http://orcid.org/0000-0002-6754-4606 Xin Li http://orcid.org/0000-0003-2525-9679
Funding Agency and Grant Number
Corresponding Author	Xin Li, MD, PhD, Director, Doctor, Department of Dermatopathology, Shanghai Dermatology Hospital, Tongji University, Institute of Dermatology, Shanghai Academy of Traditional Chinese Medicine, No. 110 Ganhe Road, Shanghai 200437, China. 13661956326@163.com
Key Words	Vitamin K1; Subcutaneous injection; Adverse reactions; Herbal medicine; Polyoxyethylated castor oil; Case report guidelines; Case report
Core Tip	Adverse cutaneous reactions to vitamin K1 can occur; however, their diagnosis can easily be overlooked. Managing these reactions may be challenging for both patients and clinicians. Here we report a patient who developed a cutaneous allergic reaction to subcutaneous vitamin K1 that was successfully treated with herbal medicine, suggesting that Chinese medicine therapy may be a feasible way to treat adverse cutaneous reactions. We confirmed our clinical findings through physical examination, a skin biopsy, and immunohistochemical staining. We also conducted a literature review of eczematous-type reactions to clarify the possible pathogenesis and provoke new thinking regarding the clinical treatment of this disease.
Publish Date	2022-09-29 09:17
Citation	Zhang M, Chen J, Wang CX, Lin NX, Li X. Cutaneous allergic reaction to subcutaneous vitamin K1: A case report and review of literature. World J Clin Cases 2022; 10(29): 10742-10754
URL	https://www.wjgnet.com/2307-8960/full/v10/i29/10742.htm
DOI	https://dx.doi.org/10.12998/wjcc.v10.i29.10742

Full Article (PDF)	WJCC-10-10742.pdf
Full Article (Word)	WJCC-10-10742.docx
Manuscript File	77911_Auto_Edited-LM.docx
Answering Reviewers	77911-Answering reviewers.pdf
Audio Core Tip	77911-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	77911-Conflict-of-interest statement.pdf
Copyright License Agreement	77911-Copyright license agreement.pdf
Signed Consent for Treatment Form(s) or Document(s)	77911-Informed consent statement.pdf
Non-Native Speakers of English Editing Certificate	77911-Language certificate.pdf
Supplementary Material	77911-Supplementary materials.pdf
Peer-review Report	77911-Peer-review(s).pdf
Scientific Editor Work List	77911-Scientific editor work list.pdf