Publication Name	World Journal of Gastroenterology
Manuscript ID	7796
Country	France

Received	2013-11-30 15:08
Peer-Review Started	2013-11-30 21:23
To Make the First Decision	2014-01-15 19:18
Return for Revision	2014-01-20 22:29
Revised	2014-02-10 23:01
Second Decision	2014-03-05 14:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-03-05 15:15
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-16 15:40
Typeset the Manuscript	2014-05-20 11:33
Publish the Manuscript Online	2014-06-16 16:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Multispecies probiotic protects gut barrier function in experimental models
Manuscript Source	Invited Manuscript
All Author List	Mylene Nébot-Vivinus, Cherryl Harkat, Hanene Bzioueche, Christel Cartier, Raffaella Plichon-Dainese, Lara Moussa, Helene Eutamene, Dorsa Pishvaie, Sophie Holowacz, Christian Seyrig, Thierry Piche and Vassilia Theodorou
Funding Agency and Grant Number	Funding Agency Grant Number PiLeJe, 37, quai-de-Grenelle, bâtiment Pollux, 75738 Paris cedex 15
Corresponding Author	Thierry Piche, Professor, Department of Gastroenterology, CHU de Nice, Hopital Archet 2, 06103 Nice, France. piche.t@chu-nice.fr
Key Words	Irritable bowel syndrome; Probiotic; Intestinal epithelial barrier permeability; Hypersensitivity
Core Tip	Some probiotics are effective in treatment of irritable bowel syndrome (IBS). The pathophysiology of IBS involves disruption of the epithelial barrier together with low grade inflammation, which represent peripheral targets for probiotics. This study aimed to elucidate the effect of a multispecies combination of bacterial strains on in vitro and in vivo models mimicking IBS. This commercialized combination was able to prevent visceral hypersensitivity and to repair the disruption to the epithelial barrier induced by lipopolysaccharide, stress or colonic soluble factors from IBS patients.
Publish Date	2014-06-16 16:19
Citation	Nébot-Vivinus M, Harkat C, Bzioueche H, Cartier C, Plichon-Dainese R, Moussa L, Eutamene H, Pishvaie D, Holowacz S, Seyrig C, Piche T, Theodorou V. Multispecies probiotic protects gut barrier function in experimental models. World J Gastroenterol 2014; 20(22): 6832-6843
URL	http://www.wjgnet.com/1007-9327/full/v20/i22/6832.htm
DOI	10.3748/wjg.v20.i22.6832

Full Article (PDF)	WJG-20-6832.pdf
Full Article (Word)	WJG-20-6832.doc
Manuscript File	7796-Review.doc
Answering Reviewers	7796-Answering reviewers.pdf
Copyright License Agreement	7796-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7796-Language certificate.pdf
Peer-review Report	7796-Peer review(s).pdf
Scientific Editor Work List	7796-Scientific editor work list.doc