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Articles Published Processes
10/12/2022 4:24:12 AM | Browse: 428 | Download: 1688
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Received |
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2022-05-30 13:01 |
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Peer-Review Started |
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2022-05-30 13:03 |
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First Decision by Editorial Office Director |
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2022-08-01 18:38 |
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Return for Revision |
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2022-08-01 18:38 |
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Revised |
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2022-08-16 13:41 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-09-20 03:34 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-09-21 16:54 |
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Articles in Press |
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2022-09-21 16:54 |
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Edit the Manuscript by Language Editor |
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2022-09-18 09:53 |
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Typeset the Manuscript |
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2022-10-08 03:33 |
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Publish the Manuscript Online |
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2022-10-12 04:24 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Hypoxia inducible factor 1α promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhao-Yang Wang, Yu Liu, Shi-Peng Li, Jian-Jun Li, Zhen Zhang, Xue-Chun Xiao, Yang Ou, Hang Wang, Jin-Zhen Cai and Shuang Yang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81670600 |
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| Corresponding Author |
Shuang Yang, PhD, Professor, Institute of Transplantation Medicine, Tianjin First Central Hospital, Nankai University, No. 94 Weijin Road, Nankai District, Tianjin 300071, China. yangshuang@mail.nankai.edu.cn |
| Key Words |
Hepatic ischemia-reperfusion injury; Interleukin-1 receptor antagonist; Hypoxia inducible factor 1α; Ischemic preconditioning |
| Core Tip |
Ischemia-reperfusion injury (IRI) is a major risk associated with liver surgery and transplantation, and its pathological mechanism is complex. Interleukin-1 receptor antagonist (IL-1ra) can protect the liver from IRI. The expression of IL-1ra was significantly upregulated after IRI in mice. Hypoxia promoted the expression of IL-1ra. Hypoxia-inducible factor (HIF)-1α accumulation contributed to increased Il-1ra transcription. Ischemic preconditioning protected the liver from IRI via the HIF-1α-IL-1ra pathway. |
| Publish Date |
2022-10-12 04:24 |
| Citation |
Wang ZY, Liu Y, Li SP, Li JJ, Zhang Z, Xiao XC, Ou Y, Wang H, Cai JZ, Yang S. Hypoxia inducible factor 1α promotes interleukin-1 receptor antagonist expression during hepatic ischemia-reperfusion injury. World J Gastroenterol 2022; 28(38): 5573-5588 |
| URL |
https://www.wjgnet.com/1007-9327/full/v28/i38/5573.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v28.i38.5573 |
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