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9/27/2022 1:00:17 PM | Browse: 179 | Download: 705
Publication Name World Journal of Clinical Cases
Manuscript ID 78091
Country/Territory South Korea
Received
2022-06-07 04:54
Peer-Review Started
2022-06-07 04:57
To Make the First Decision
Return for Revision
2022-07-12 01:03
Revised
2022-07-26 14:54
Second Decision
2022-08-17 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-17 17:19
Articles in Press
2022-08-17 17:19
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-09-14 08:15
Publish the Manuscript Online
2022-09-27 13:00
ISSN 2307-8960 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Retrospective Study
Article Title Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List Hee Ryeong Jang, Hui-Young Lee, Seo-Young Song and Kyu-Hyoung Lim
ORCID
Author(s) ORCID Number
Hee Ryeong Jang http://orcid.org/0000-0001-8162-8657
Hui-Young Lee http://orcid.org/0000-0001-6454-8030
Seo-Young Song http://orcid.org/0000-0002-6981-3224
Kyu-Hyoung Lim http://orcid.org/0000-0001-8284-9198
Funding Agency and Grant Number
Corresponding Author Kyu-Hyoung Lim, MD, PhD, Professor, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon-si, 156 Baengnyeong-ro, Gangwon-do 24289, South Korea. kyuhyoung.lim@kangwon.ac.kr
Key Words Combination chemotherapy; Targeted agent; Colorectal cancer; Salvage chemotherapy; Elderly patient
Core Tip This study assessed the clinical outcomes of combination chemotherapy and feasibility of target agent (TA) in extremely elderly patients (defined as ≥ 80 years of age) with for metastatic colorectal cancer. The median progression-free survival (PFS) and overall survival (OS) in patients treated with TA were 7.4 mo and 15.4 mo, respectively, compared with 4.4 mo and 15.6 mo, respectively, in patients treated without TA. There was no significant difference in PFS (P: 0.193) and OS (P: 0.748) rates. Targeted therapies may be considered with careful caution even in elderly patients. After disease progression, salvage chemotherapy may help improve OS in some selected of these elderly patients.
Publish Date 2022-09-27 13:00
Citation Jang HR, Lee HY, Song SY, Lim KH. Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer. World J Clin Cases 2022; 10(28): 10066-10076
URL https://www.wjgnet.com/2307-8960/full/v10/i28/10066.htm
DOI https://dx.doi.org/10.12998/wjcc.v10.i28.10066
Full Article (PDF) WJCC-10-10066.pdf
Full Article (Word) WJCC-10-10066.docx
Manuscript File 78091_Auto_Edited-LM.docx
Answering Reviewers 78091-Answering reviewers.pdf
Audio Core Tip 78091-Audio core tip.m4a
Biostatistics Review Certificate 78091-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 78091-Conflict-of-interest statement.pdf
Copyright License Agreement 78091-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 78091-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 78091-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 78091-Language certificate.pdf
Peer-review Report 78091-Peer-review(s).pdf
Scientific Misconduct Check 78091-Bing-Wang LL-2.png
Scientific Editor Work List 78091-Scientific editor work list.pdf