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Articles Published Processes
9/27/2022 1:00:17 PM | Browse: 324 | Download: 1121
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Received |
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2022-06-07 04:54 |
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Peer-Review Started |
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2022-06-07 04:57 |
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To Make the First Decision |
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Return for Revision |
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2022-07-12 01:03 |
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Revised |
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2022-07-26 14:54 |
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Second Decision |
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2022-08-17 03:16 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2022-08-17 17:19 |
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Articles in Press |
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2022-08-17 17:19 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-09-14 08:15 |
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Publish the Manuscript Online |
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2022-09-27 13:00 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hee Ryeong Jang, Hui-Young Lee, Seo-Young Song and Kyu-Hyoung Lim |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Kyu-Hyoung Lim, MD, PhD, Professor, Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon-si, 156 Baengnyeong-ro, Gangwon-do 24289, South Korea. kyuhyoung.lim@kangwon.ac.kr |
| Key Words |
Combination chemotherapy; Targeted agent; Colorectal cancer; Salvage chemotherapy; Elderly patient |
| Core Tip |
This study assessed the clinical outcomes of combination chemotherapy and feasibility of target agent (TA) in extremely elderly patients (defined as ≥ 80 years of age) with for metastatic colorectal cancer. The median progression-free survival (PFS) and overall survival (OS) in patients treated with TA were 7.4 mo and 15.4 mo, respectively, compared with 4.4 mo and 15.6 mo, respectively, in patients treated without TA. There was no significant difference in PFS (P: 0.193) and OS (P: 0.748) rates. Targeted therapies may be considered with careful caution even in elderly patients. After disease progression, salvage chemotherapy may help improve OS in some selected of these elderly patients. |
| Publish Date |
2022-09-27 13:00 |
| Citation |
Jang HR, Lee HY, Song SY, Lim KH. Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer. World J Clin Cases 2022; 10(28): 10066-10076 |
| URL |
https://www.wjgnet.com/2307-8960/full/v10/i28/10066.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v10.i28.10066 |
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