Publication Name	World Journal of Transplantation
Manuscript ID	78241
Country	Greece

Received	2022-06-15 19:34
Peer-Review Started	2022-06-15 19:37
To Make the First Decision
Return for Revision	2022-08-01 09:31
Revised	2022-08-10 16:58
Second Decision	2022-10-19 03:50
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-19 17:37
Articles in Press	2022-10-19 17:37
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-11-07 16:59
Typeset the Manuscript	2022-11-13 23:56
Publish the Manuscript Online	2022-11-17 04:40

ISSN	2220-3230 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of immunotherapy in downsizing hepatocellular carcinoma prior to liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Konstantinos Ouranos, Anthi Chatziioannou, Ioannis Goulis and Emmanouil Sinakos
ORCID	Author(s) ORCID Number Konstantinos Ouranos http://orcid.org/0000-0001-9034-5026 Anthi Chatziioannou http://orcid.org/0000-0002-8931-6786 Ioannis Goulis http://orcid.org/0000-0002-2765-4157 Emmanouil Sinakos http://orcid.org/0000-0003-0923-050X
Funding Agency and Grant Number
Corresponding Author	Konstantinos Ouranos, MD, N/A, N/A, 4th Medical Department, Hippokratio Hospital, Aristotle University of Thessaloniki, 49, Konstantinoupoleos Str, Thessaloniki 54642, Greece. kostassky@hotmail.com
Key Words	Hepatocellular carcinoma; Immunotherapy; Tumor downsizing; Liver transplantation; Neoadjuvant; Rejection
Core Tip	Immunotherapy has been used in the treatment of advanced hepatocellular carcinoma (HCC) with promising results. Extending its use in the preoperative period prior to liver transplantation (LT), either alone or in combination with other locoregional treatment modalities, could increase the pool of potential LT candidates. Data from case reports and ongoing clinical trials assessing neoadjuvant immunotherapy prior to LT could revolutionize the current consensus regarding HCC downsizing practices and improve survival of patients with this type of malignancy.
Publish Date	2022-11-17 04:40
Citation	Ouranos K, Chatziioannou A, Goulis I, Sinakos E. Role of immunotherapy in downsizing hepatocellular carcinoma prior to liver transplantation. World J Transplant 2022; 12(11): 331-346
URL	https://www.wjgnet.com/2220-3230/full/v12/i11/331.htm
DOI	https://dx.doi.org/10.5500/wjt.v12.i11.331

Full Article (PDF)	WJT-12-331.pdf
Full Article (Word)	WJT-12-331.docx
Manuscript File	78241_Auto_Edited-LM_Kerr C_Clear Copy.docx
Answering Reviewers	78241-Answering reviewers.pdf
Audio Core Tip	78241-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	78241-Conflict-of-interest statement.pdf
Copyright License Agreement	78241-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate	78241-Language certificate .pdf
Peer-review Report	78241-Peer-review(s).pdf
Scientific Misconduct Check	78241-Bing-Ma YJ-2.png
Scientific Editor Work List	78241-Scientific editor work list .pdf
CrossCheck Report	78241-CrossCheck Report.pdf