Publication Name	World Journal of Gastroenterology
Manuscript ID	7829
Country	Norway

Received	2013-12-02 18:44
Peer-Review Started	2013-12-03 18:54
First Decision by Editorial Office Director
Return for Revision
Revised	2014-02-11 03:02
Publication Fee Transferred
Second Decision by Editor	2014-03-10 14:07
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2014-03-10 17:16
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-03-31 15:26
Publish the Manuscript Online	2014-04-14 10:49

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation
Manuscript Source	Invited Manuscript
All Author List	Bjarte Fosby, Sigrid Næss, Johannes R Hov, James Traherne, Kirsten M Boberg, John Trowsdale, Aksel Foss, Pål-Dag Line, Andre Franke, Espen Melum, Helge Scott and Tom H Karlsen
Funding Agency and Grant Number	Funding Agency Grant Number Norwegian PSC Research Center Wellcome Trust and the MRC with additional support from the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre to Traherne J and Trowsdale J
Corresponding Author	Tom H Karlsen, MD, PhD, Professor, Norwegian PSC Research Center, Division of Cancer, Surgery and Transplantation, Oslo University Hospital, Rikshospitalet, Pb 4950 Nydalen, N-0424 Oslo, Norway. t.h.karlsen@medisin.uio.no
Key Words	Liver transplantation; Primary sclerosing cholangitis; Acute rejection; Human leukocyte antigen; Killer immunoglobulin-like receptor
Core Tip	Patients undergoing liver transplantation on the basis of primary sclerosing cholangitis (PSC) have a higher frequency of acute cellular rejections than non-PSC patients. Recent studies have determined the genetic susceptibility to PSC, of which genetic variants in the human leukocyte antigen complex represent the strongest risk factors. In the present report we show that these variants also influence risk of acute cellular rejection after liver transplantation in PSC. Moreover, we show that the same variants also involve in risk of acute cellular rejection in non-PSC recipients.
Publish Date	2014-04-14 10:49
Citation	Fosby B, N?ss S, Hov JR, Traherne J, Boberg KM, Trowsdale J, Foss A, Line PD, Franke A, Melum E, Scott H, Karlsen TH. HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation. World J Gastroenterol 2014; 20(14): 3986-4000
URL	http://www.wjgnet.com/1007-9327/full/v20/i14/3986.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i14.3986

Full Article (PDF)	WJG-20-3986.pdf
Full Article (Word)	WJG-20-3986.doc
Manuscript File	7829-Review.doc
Answering Reviewers	7829-Answering reviewers.pdf
Copyright License Agreement	7829-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7829-Language certificate.pdf
Peer-review Report	7829-Peer review(s).pdf