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Articles Published Processes
3/23/2023 8:29:43 AM | Browse: 349 | Download: 1307
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Received |
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2022-06-30 14:07 |
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Peer-Review Started |
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2022-06-30 14:10 |
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First Decision by Editorial Office Director |
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2022-12-30 05:44 |
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Return for Revision |
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2022-12-30 05:44 |
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Revised |
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2023-01-06 11:06 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2023-02-08 03:37 |
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Second Decision by Editor-in-Chief |
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2023-02-09 01:57 |
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Final Decision by Editorial Office Director |
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2023-02-16 19:19 |
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Articles in Press |
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2023-02-16 19:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2023-03-20 01:55 |
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Publish the Manuscript Online |
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2023-03-23 08:29 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Tao Zhang, Qian Zhang and Wan-Cheng Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Natural Science Foundation of Shandong Province of China |
ZR2021QH179 |
| Natural Science Foundation of Shandong Province of China |
ZR2020MH014 |
| Natural Science Foundation of Shandong Province of China |
ZR2021MH182 |
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| Corresponding Author |
Wan-Cheng Yu, Doctor, MD, Surgeon, Department of Cardiovascular Surgery, Shandong Provincial Hospital, No. 324 Jingwu Weiqi Road, Jinan 250062, Shandong Province, China. yuwancheng123@126.com |
| Key Words |
Mouse bone marrow mesenchymal stem cell; Mammalian sterile 20-like kinase 1; Anoikis; Integrin; Autophagy; Reactive oxygen species |
| Core Tip |
In isolated mouse bone marrow mesenchymal stem cell (mBMSCs), Mammalian sterile 20-like kinase 1 (Mst1) inhibition could ameliorate not only autophagy formation but also upregulate integrin (ITG) α5β1 expression (but not ITGα4, ITGαv, or ITGβ3). In addition, Mst1 inhibition-induced autophagy could scavenge the excessive production of ITGα5β1-triggered ROS. Therefore, Mst1 inhibition-based infusion may improve the survival of MSCs, thereby serving as an ideal candidate for clinical transplantation in pulmonary arterial hypertension. |
| Publish Date |
2023-03-23 08:29 |
| Citation |
Zhang T, Zhang Q, Yu WC. Mammalian Ste20-like kinase 1 inhibition as a cellular mediator of anoikis in mouse bone marrow mesenchymal stem cells. World J Stem Cells 2023; 15(3): 90-104 |
| URL |
https://www.wjgnet.com/1948-0210/full/v15/i3/90.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v15.i3.90 |
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