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Articles Published Processes
9/9/2022 12:48:15 PM | Browse: 634 | Download: 1317
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Received |
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2022-06-18 18:39 |
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Peer-Review Started |
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2022-06-18 18:42 |
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First Decision by Editorial Office Director |
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2022-07-19 16:52 |
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Return for Revision |
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2022-07-19 16:52 |
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Revised |
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2022-07-28 13:32 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2022-08-08 03:09 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2022-08-17 23:47 |
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Articles in Press |
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2022-08-17 23:47 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2022-08-26 01:37 |
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Publish the Manuscript Online |
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2022-09-09 12:48 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Nutrition deprivation affects the cytotoxic effect of CD8 T cells in hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Chun-Ye Zhang, Shuai Liu and Ming Yang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Ming Yang, DVM, PhD, Postdoctoral Fellow, Department of Surgery, University of Missouri, Room 2203, NexGen Precision Building, 1030 Hitt Street, Columbia, MO 65211, United States. yangmin@health.missouri.edu |
| Key Words |
Hepatocellular carcinoma; Metabolism; Amino acids; Tumor microenvironment; T cell function |
| Core Tip |
Immunotherapy is one of the most powerful tools for patients with unresectable hepatocellular carcinoma. CD8+ T cells are a major immune component in the tumor microenvironment with cytotoxic effects against tumor cells. However, these CD8+ T cells commonly display an exhaustion phenotype with high expression of immune checkpoints such as programmed cell death protein 1, producing less anti-tumor proteins and cytokines, such as perforin and granzyme B. Here, we show that the roles of amino acids such as glutamine in T cell activation and function are dependent on tumor types and nutrients in the tumor microenvironment. Overall, nutrient metabolism reprogramming in the tumor microenvironment plays a pivotal role in both tumor growth and immune response. |
| Publish Date |
2022-09-09 12:48 |
| Citation |
Zhang CY, Liu S, Yang M. Nutrition deprivation affects the cytotoxic effect of CD8 T cells in hepatocellular carcinoma. World J Gastrointest Oncol 2022; 14(9): 1887-1891 |
| URL |
https://www.wjgnet.com/1948-5204/full/v14/i9/1887.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v14.i9.1887 |
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