Publication Name	World Journal of Gastroenterology
Manuscript ID	7830
Country	South Korea

Received	2013-12-02 18:52
Peer-Review Started	2013-12-03 18:59
To Make the First Decision	2014-01-15 17:29
Return for Revision	2014-01-21 10:19
Revised	2014-02-27 08:23
Second Decision	2014-04-09 09:24
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-04-09 11:04
Articles in Press	2014-05-23 10:47
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-04-23 16:57
Typeset the Manuscript	2014-06-27 14:34
Publish the Manuscript Online	2014-07-14 17:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer
Manuscript Source	Invited Manuscript
All Author List	Woo Hyun Paik, Ji Kon Ryu, Kyoung-Sin Jeong, Jin Myung Park, Byeong Jun Song, Sang Hyub Lee, Yong-Tae Kim and Yong Bum Yoon
Funding Agency and Grant Number	Funding Agency Grant Number Korean Society of Internal Medicine Research Fund (2012) Seoul National University College of Medicine Research Fund (2011)
Corresponding Author	Ji Kon Ryu, MD, PhD, Associate Professor, Division of Gastroenterology, Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul 110-744, South Korea. jkryu@snu.ac.kr
Key Words	Clobenpropit; Epithelial-mesenchymal transition; Histamine; Histamine receptors; Pancreatic neoplasm
Core Tip	Histamine is associated with carcinogenesis through activation of its 4 membrane-specific receptors. Clobenpropit, which is an agonist of H4 receptor, inhibited cell migration and increased apoptosis of pancreatic cancer cells in combination with gemcitabine. Clobenpropit up-regulated an epithelial marker, but down-regulated mesenchymal markers in real-time polymerase chain reaction. In addition, clobenpropit inhibited tumor growth and enhanced apoptosis in combination with gemcitabine by up-regulation of E-cadherin and down-regulation of Zeb1 in Panc-1 xenograft mouse. In conclusion, clobenpropit enhanced anti-tumor effects of gemcitabine in pancreatic cancer cells through inhibition of epithelial-mesenchymal transition process.
Publish Date	2014-07-14 17:39
Citation	Paik WH, Ryu JK, Jeong KS, Park JM, Song BJ, Lee SH, Kim YT, Yoon YB. Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer. World J Gastroenterol 2014; 20(26): 8545-8557
URL	http://www.wjgnet.com/1007-9327/full/v20/i26/8545.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i26.8545

Full Article (PDF)	WJG-20-8545.pdf
Full Article (Word)	WJG-20-8545.doc
Manuscript File	7830-Review.doc
Answering Reviewers	7830-Answering reviewers.pdf
Copyright License Agreement	7830-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	7830-Language certificate.pdf
Peer-review Report	7830-Peer review(s).pdf
Scientific Editor Work List	7830-Scientific editor work list.doc