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Articles Published Processes
3/28/2023 12:59:29 PM | Browse: 106 | Download: 248
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Received |
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2022-06-20 05:39 |
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Peer-Review Started |
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2022-06-20 05:42 |
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To Make the First Decision |
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Return for Revision |
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2022-08-01 05:41 |
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Revised |
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2022-08-04 08:46 |
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Second Decision |
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2023-03-13 03:13 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2023-03-13 16:50 |
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Articles in Press |
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2023-03-13 16:50 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2022-10-28 05:09 |
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Typeset the Manuscript |
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2023-03-20 09:01 |
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Publish the Manuscript Online |
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2023-03-28 12:59 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Mitochondrial carnitine palmitoyltransferase-II dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Min Yao, Ping Zhou, Yan-Yan Qin, Li Wang and Deng-Fu Yao |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81873915 |
| National Natural Science Foundation of China |
31872738 |
| Key Plan of Nantong S &T Development |
MS12020021 |
| S&T Program of Medical School of Nantong University |
TDYX2021010 |
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| Corresponding Author |
Deng-Fu Yao, MD, PhD, Director, Full Professor, Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, No. 20 West Temple Road, Nantong 226001, Jiangsu Province, China. yaodf@ahnmc.com |
| Key Words |
Carnitine palmitoyl transferase-II; Nonalcoholic fatty liver disease; Fatty acid β-oxidation; Carnitine; Hepatocyte malignant transformation; Mitochondrial membrane |
| Core Tip |
The complex mechanisms of nonalcoholic fatty liver disease formation are still under identification. Hepatic carnitine palmitoyl transferase-II (CPT-II) on inner mitochondrial membrane regulates long chain fatty acid β-oxidation and this abnormality has had more attention paid to it by basic and clinical research. The sequences of its peptide chain and DNA nucleotides have been identified and the catalytic activity of CPT-II is affected on its gene mutations, deficiency, enzymatic thermal instability, circulating carnitine level and so on. CPT-II dysfunction has been discovered in models of lipid accumulation. Meanwhile, the malignant transformation of hepatocyte-related CD44+ stem T cell activation, high levels of tumor-related biomarkers and abnormal Wnt3a expression as a key signal molecule of the Wnt/β-catenin pathway run parallel to the alterations of hepatocyte pathology. |
| Publish Date |
2023-03-28 12:59 |
| Citation |
Yao M, Zhou P, Qin YY, Wang L, Yao DF. Mitochondrial carnitine palmitoyltransferase-II dysfunction: A possible novel mechanism for nonalcoholic fatty liver disease in hepatocarcinogenesis. World J Gastroenterol 2023; 29(12): 1765-1778 |
| URL |
https://www.wjgnet.com/1007-9327/full/v29/i12/1765.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v29.i12.1765 |
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