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10/14/2022 12:54:50 PM | Browse: 239 | Download: 964
Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 78390
Country/Territory China
Received
2022-06-24 06:06
Peer-Review Started
2022-06-24 06:09
To Make the First Decision
Return for Revision
2022-07-18 17:00
Revised
2022-07-29 17:16
Second Decision
2022-08-17 03:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2022-08-17 18:58
Articles in Press
2022-08-17 18:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2022-10-08 07:17
Publish the Manuscript Online
2022-10-14 12:54
ISSN 1948-5204 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Mathematical & Computational Biology
Manuscript Type Basic Study
Article Title Cuproptosis-related long non-coding RNAs model that effectively predicts prognosis in hepatocellular carcinoma
Manuscript Source Unsolicited Manuscript
All Author List En-Min Huang, Ning Ma, Tao Ma, Jun-Yi Zhou, Wei-Sheng Yang, Chuang-Xiong Liu, Ze-Hui Hou, Shuang Chen, Zhen Zong, Bing Zeng, Ying-Ru Li and Tai-Cheng Zhou
ORCID
Author(s) ORCID Number
En-Min Huang http://orcid.org/0000-0003-0570-3138
Ning Ma http://orcid.org/0000-0002-6305-7915
Tao Ma http://orcid.org/0000-0002-6890-0289
Jun-Yi Zhou http://orcid.org/0000-0002-0024-9338
Wei-Sheng Yang http://orcid.org/0000-0001-9314-8191
Chuang-Xiong Liu http://orcid.org/0000-0002-4103-9062
Ze-Hui Hou http://orcid.org/0000-0003-0298-0236
Shuang Chen http://orcid.org/0000-0002-7013-5774
Zhen Zong http://orcid.org/0000-0001-8953-7792
Bing Zeng http://orcid.org/0000-0003-4167-5330
Ying-Ru Li http://orcid.org/0000-0003-0583-703X
Tai-Cheng Zhou http://orcid.org/0000-0003-0582-1150
Funding Agency and Grant Number
Funding Agency Grant Number
National Key Clinical Discipline, the Basic and Applied Basic Research Fund Project of Guangdong Province 2021A1515410004
National Natural Science Foundation of China 81973858
Science and Technology Plan Project of Qingyuan City 2019A028
Basic and Applied Basic Research Fund Project of Guangdong Province 2019A1515011200
Science and Technology Plan Project of Qingyuan City 2019A028
Corresponding Author Tai-Cheng Zhou, MD, PhD, Associate Professor, Doctor, Surgeon, Surgical Oncologist, Department of Gastroenterological Surgery and Hernia Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Street Address, Guangzhou 510655, Guangdong Province, China. zhoutch3@mail.sysu.edu.cn
Key Words Hepatocellular carcinoma; Cuproptosis; Long-chain non-coding RNAs; Prognosis; Tumor microenvironment; Immunotherapy
Core Tip Factors crucial to the regulation of cuproptosis remain unelucidated. Using transcriptome data from The Cancer Genome Atlas (TCGA-LIHC), we developed a cuproptosis- and prognosis-related long-chain non-coding RNAs signature (CupRLSig) for hepatocellular carcinoma. The high-risk group identified by CupRLSig was associated with poorer overall survival and progression-free survival. Less activation of natural killer cells and more infiltration of regulatory T cells in the high-risk group may explain the worse outcomes. Interestingly, based on checkpoint gene expression (CD276, CTLA-4, and PDCD-1) and tumor immune dysfunction and rejection, high-risk patients may respond better to immunotherapy.
Publish Date 2022-10-14 12:54
Citation Huang EM, Ma N, Ma T, Zhou JY, Yang WS, Liu CX, Hou ZH, Chen S, Zong Z, Zeng B, Li YR, Zhou TC. Cuproptosis-related long non-coding RNAs model that effectively predicts prognosis in hepatocellular carcinoma. World J Gastrointest Oncol 2022; 14(10): 1981-2003
URL https://www.wjgnet.com/1948-5204/full/v14/i10/1981.htm
DOI https://dx.doi.org/10.4251/wjgo.v14.i10.1981
Full Article (PDF) WJGO-14-1981.pdf
Full Article (Word) WJGO-14-1981.docx
Manuscript File 78390_Auto_Edited-LM.docx
Answering Reviewers 78390-Answering reviewers.pdf
Audio Core Tip 78390-Audio core tip.mp3
Biostatistics Review Certificate 78390-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 78390-Conflict-of-interest statement.pdf
Copyright License Agreement 78390-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 78390-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 78390-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 78390-Language certificate.pdf
Supplementary Material 78390-Supplementary material.pdf
Peer-review Report 78390-Peer-review(s).pdf
Scientific Misconduct Check 78390-Bing-Chen YL-2.png
Scientific Editor Work List 78390-Scientific editor work list.pdf