Publication Name	World Journal of Gastroenterology
Manuscript ID	7849
Country	China

Received	2013-12-02 20:00
Peer-Review Started	2013-12-04 16:22
To Make the First Decision	2014-01-09 15:14
Return for Revision	2014-01-23 09:37
Revised	2014-01-30 00:36
Second Decision	2014-03-06 17:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-03-06 18:11
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2014-03-18 17:21
Typeset the Manuscript	2014-05-02 21:45
Publish the Manuscript Online	2014-05-18 12:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Autobiography
Article Title	Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer
Manuscript Source	Invited Manuscript
All Author List	Wang-Kai Fang, Lian-Di Liao, Wei Gu, Bo Chen, Zhi-Yong Wu, Jian-Yi Wu, Jian Shen, Li-Yan Xu and En-Min Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81101613 Guangdong Provincial Natural Science Foundation of China S2011040004363 Specialized Research Fund for the Doctoral Program of Higher Education of China 20114402120005 National Basic Research Program of China 2012CB526600 Natural Science Foundation of China-Guangdong Joint Fund U0932001
Corresponding Author	En-Min Li, PhD, Department of Biochemistry and Molecular Biology, The Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area, Shantou University Medical College, Xinling Rd 22, Shantou 515041, Guangdong Province, China. nmli@stu.edu.cn
Key Words	γ-catenin; Esophageal squamous cell carcinoma; Independent prognostic factor; Cell-cell adhesion; Cell migration
Core Tip	We, like others, have shown in previous work that reduced classic and desmosomal cadherin expression correlated with increased metastasis both in laboratory models and in clinical esophageal squamous cell carcinoma (ESCC) samples; however, a direct functional role of γ-catenin in this process has not been shown. In this study, we report that γ-catenin plays a critical role in ESCC progression. Our work demonstrates that γ-catenin is a tumor metastasis suppressor in ESCC and its expression may serve as a prognostic marker. Loss of γ-catenin leads to significant changes in esophageal cancer cell phenotypes.
Publish Date	2014-05-18 12:31
Citation	Fang WK, Liao LD, Gu W, Chen B, Wu ZY, Wu JY, Shen J, Xu LY, Li EM. Down-regulated γ-catenin expression is associated with tumor aggressiveness in esophageal cancer. World J Gastroenterol 2014; 20(19): 5839-5848
URL	http://www.wjgnet.com/1007-9327/full/v20/i19/5839.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i19.5839

Full Article (PDF)	WJG-20-5839.pdf
Full Article (Word)	WJG-20-5839.doc
Manuscript File	7849-Review.doc
Answering Reviewers	7849-Answering reviewers.pdf
Copyright License Agreement	7849-Copyright assignment.pdf
Peer-review Report	7849-Peer reviews.pdf
Scientific Editor Work List	7849-Scientific editor work list.doc