ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved. |
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Basic Study |
Article Title |
Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis
|
Manuscript Source |
Unsolicited Manuscript |
All Author List |
Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang and Lei Shi |
ORCID |
|
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
13th Five-Year Plan for National Key R&D Program of China |
2018YFC1705405 |
Scientific Research Innovation Team Project of Beijing University of Chinese Medicine |
2019-JYB-TD004 |
New Faculty Startup Fund Program of BUCM |
2022-JYB-XJSJJ078 |
National Natural Science Foundation of China |
82004113 |
|
Corresponding Author |
Lei Shi, MD, PhD, Research Assistant, Research Associate, Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6 Fangxingyuan Zone 1, Fangzhuang, Fengtai District, Beijing 100078, China. b01350@bucm.edu.cn |
Key Words |
Ulcerative colitis; Gut microbiota; Metabolites; Dextran sulfate sodium; Mucin |
Core Tip |
We observed that the differences in microbiota and their metabolites can cause different degrees of colitis. The differential metabolites of the microbiota in colitis are mainly enriched in pathways related to the key structural sequence synthesis of mucin, and the different levels of the metabolites lead to differential expression of mucin and mucus. Therefore, the differential metabolites of colitis could regulate the composition and function of mucus. In addition, the differential intestinal microbiota and their metabolites in mice with colitis were largely associated with amino acid and energy metabolism. |
Publish Date |
2022-11-16 11:26 |
Citation |
Wang JL, Han X, Li JX, Shi R, Liu LL, Wang K, Liao YT, Jiang H, Zhang Y, Hu JC, Zhang LM, Shi L. Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis. World J Gastroenterol 2022; 28(43): 6109-6130 |
URL |
https://www.wjgnet.com/1007-9327/full/v28/i43/6109.htm |
DOI |
https://dx.doi.org/10.3748/wjg.v28.i43.6109 |