Publication Name	World Journal of Gastroenterology
Manuscript ID	78506
Country	China

Received	2022-07-12 09:06
Peer-Review Started	2022-07-12 09:10
First Decision by Editorial Office Director	2022-09-26 07:45
Return for Revision	2022-09-26 07:45
Revised	2022-10-04 07:43
Publication Fee Transferred
Second Decision by Editor	2022-11-03 03:19
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2022-11-03 20:58
Articles in Press	2022-11-03 20:58
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-14 08:33
Publish the Manuscript Online	2022-11-16 11:26

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Li Wang, Xiao Han, Jun-Xiang Li, Rui Shi, Lei-Lei Liu, Kai Wang, Yu-Ting Liao, Hui Jiang, Yang Zhang, Jun-Cong Hu, Li-Ming Zhang and Lei Shi
ORCID	Author(s) ORCID Number Jia-Li Wang http://orcid.org/0000-0002-2789-5081 Xiao Han http://orcid.org/0000-0003-1340-9692 Jun-Xiang Li http://orcid.org/0000-0001-7590-9444 Rui Shi http://orcid.org/0000-0002-9374-0897 Lei-Lei Liu http://orcid.org/0000-0003-4639-5370 Kai Wang http://orcid.org/0000-0001-5510-7719 Yu-Ting Liao http://orcid.org/0000-0003-1821-048X Hui Jiang http://orcid.org/0000-0003-3755-8975 Yang Zhang http://orcid.org/0000-0002-2704-9846 Jun-Cong Hu http://orcid.org/0000-0002-2493-5535 Li-Ming Zhang http://orcid.org/0000-0003-2039-7124 Lei Shi http://orcid.org/0000-0002-7925-5166
Funding Agency and Grant Number	Funding Agency Grant Number 13th Five-Year Plan for National Key R&D Program of China 2018YFC1705405 Scientific Research Innovation Team Project of Beijing University of Chinese Medicine 2019-JYB-TD004 New Faculty Startup Fund Program of BUCM 2022-JYB-XJSJJ078 National Natural Science Foundation of China 82004113
Corresponding Author	Lei Shi, MD, PhD, Research Assistant, Research Associate, Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, No. 6 Fangxingyuan Zone 1, Fangzhuang, Fengtai District, Beijing 100078, China. b01350@bucm.edu.cn
Key Words	Ulcerative colitis; Gut microbiota; Metabolites; Dextran sulfate sodium; Mucin
Core Tip	We observed that the differences in microbiota and their metabolites can cause different degrees of colitis. The differential metabolites of the microbiota in colitis are mainly enriched in pathways related to the key structural sequence synthesis of mucin, and the different levels of the metabolites lead to differential expression of mucin and mucus. Therefore, the differential metabolites of colitis could regulate the composition and function of mucus. In addition, the differential intestinal microbiota and their metabolites in mice with colitis were largely associated with amino acid and energy metabolism.
Publish Date	2022-11-16 11:26
Citation	Wang JL, Han X, Li JX, Shi R, Liu LL, Wang K, Liao YT, Jiang H, Zhang Y, Hu JC, Zhang LM, Shi L. Differential analysis of intestinal microbiota and metabolites in mice with dextran sulfate sodium-induced colitis. World J Gastroenterol 2022; 28(43): 6109-6130
URL	https://www.wjgnet.com/1007-9327/full/v28/i43/6109.htm
DOI	https://dx.doi.org/10.3748/wjg.v28.i43.6109

Full Article (PDF)	WJG-28-6109.pdf
Full Article (Word)	WJG-28-6109.docx
The ARRIVE Guidelines	78506-The-ARRIVE-Guidelines-revision.pdf
Manuscript File	78506_Auto_Edited-LM.docx
Answering Reviewers	78506-Answering reviewers.pdf
Audio Core Tip	78506-Audio core tip.mp3
Biostatistics Review Certificate	78506-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	78506-Conflict-of-interest statement.pdf
Copyright License Agreement	78506-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document	78506-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	78506-Language certificate.pdf
Peer-review Report	78506-Peer-review(s).pdf
CrossCheck Report	78506-CrossCheck report.pdf