Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	78550
Country	China

Received	2022-07-04 13:37
Peer-Review Started	2022-07-04 13:39
To Make the First Decision
Return for Revision	2022-08-13 22:01
Revised	2022-08-24 15:30
Second Decision	2022-10-10 03:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-10-11 17:06
Articles in Press	2022-10-11 17:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-11-04 06:58
Publish the Manuscript Online	2022-11-15 10:19

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Synaptophysin-like 2 expression correlates with lymph node metastasis and poor prognosis in colorectal cancer patients
Manuscript Source	Unsolicited Manuscript
All Author List	Zong-Xian Zhao, Qin-Lingfei Liu, Yao Yuan and Fu-Sheng Wang
ORCID	Author(s) ORCID Number Zong-Xian Zhao http://orcid.org/0000-0001-7553-2085
Funding Agency and Grant Number
Corresponding Author	Zong-Xian Zhao, MD, Researcher, Surgeon, Department of Anorectal Surgery, Fuyang People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. 461901590@qq.com
Key Words	Synaptophysin-like 2; Colorectal cancer; Lymph node metastasis; Prognosis; Immune microenvironment; Bevacizumab
Core Tip	In this research, we reported the expression and biofunctions of synaptophysin-like 2 (SYPL2) in colorectal cancer (CRC) for the first time. SYPL2 correlated with lymph node metastasis and a poor prognosis (both overall and disease-free survival) in CRC. SYPL2 mainly influence CD8 T-cell and M0 macrophage enrichment in the tumor microenvironment. Gene set enrichment analysis indicated that SYPL2 might also influence the tumor vasculature development. In addition, we found that SYPL2 was correlated with the effect of bevacizumab therapy.
Publish Date	2022-11-15 10:19
Citation	Zhao ZX, Liu QL, Yuan Y, Wang FS. Synaptophysin-like 2 expression correlates with lymph node metastasis and poor prognosis in colorectal cancer patients. World J Gastrointest Oncol 2022; 14(11): 2122-2137
URL	https://www.wjgnet.com/1948-5204/full/v14/i11/2122.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i11.2122

Full Article (PDF)	WJGO-14-2122.pdf
Full Article (Word)	WJGO-14-2122.docx
Manuscript File	78550_Auto_Edited-LM.docx
Answering Reviewers	78550-Answering reviewers.pdf
Audio Core Tip	78550-Audio core tip.mp3
Biostatistics Review Certificate	78550-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	78550-Conflict-of-interest statement.pdf
Copyright License Agreement	78550-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document	78550-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	78550-Language certificate.pdf
Peer-review Report	78550-Peer-review(s).pdf
Scientific Misconduct Check	78550-Bing-Wang JJ-2.png
Scientific Editor Work List	78550-Scientific editor work list.pdf
CrossCheck Report	78550-CrossCheck report.pdf