Publication Name	World Journal of Orthopedics
Manuscript ID	78605
Country	United States

Received	2022-07-11 23:32
Peer-Review Started	2022-07-11 23:34
To Make the First Decision
Return for Revision	2022-08-01 09:00
Revised	2022-08-07 15:55
Second Decision	2022-08-25 03:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2022-08-25 20:58
Articles in Press	2022-08-25 20:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2022-09-04 08:31
Publish the Manuscript Online	2022-09-16 12:55

ISSN	2218-5836 (online)
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Category	Orthopedics
Manuscript Type	Case Report
Article Title	Calcium pyrophosphate dihydrate crystals in a 9-year-old with osteomyelitis of the knee: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	William Pavlis, David S. Constantinescu, Rajan Murgai, Spencer Barnhill and Brian Black
ORCID	Author(s) ORCID Number William Pavlis http://orcid.org/0000-0003-3465-7871
Funding Agency and Grant Number
Corresponding Author	William Pavlis, N/A, N/A, N/A, Department of Orthopaedics, University of Miami, 1611 NW 12th Ave #303, Miami, 33136, United States. wwp7@med.miami.edu
Key Words	Calcium pyrophosphate; Pseudogout; Pediatrics; Crystals; Osteomyelitis; Case report
Core Tip	CPPD is rarely seen in patients under the age of 40. This case represents a rare diagnostic finding of CPP crystals in a 9-year-old patient. Previously, the youngest patients ever described in case reports were 16 years old. In the rare cases presented of young patients with CPPD, genetic predisposition or related metabolic conditions were almost always identified. In this case, the presence of osteomyelitis presents a unique insight into the pathogenesis of these crystals in pediatric patients. This case highlights the need for more research on the pathogenesis of these crystals and their role in pediatric arthritis and joint infection.
Publish Date	2022-09-16 12:55
Citation	Pavlis W, Constantinescu DS, Murgai R, Barnhill S, Black B. Calcium pyrophosphate dihydrate crystals in a 9-year-old with osteomyelitis of the knee: A case report. World J Orthop 2022; 13(9): 870-875
URL	https://www.wjgnet.com/2218-5836/full/v13/i9/870.htm
DOI	https://dx.doi.org/10.5312/wjo.v13.i9.870

Full Article (PDF)	WJO-13-870.pdf
Full Article (Word)	WJO-13-870.docx
CARE Checklist–2016	78605-CARE-Checklist–2016-revision.pdf
Manuscript File	78605_Auto_Edited-LS.docx
Answering Reviewers	78605-Answering reviewers.pdf
Audio Core Tip	78605-Audio core tip.mp4
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