Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	78685
Country	China

Received	2022-07-09 17:55
Peer-Review Started	2022-07-09 17:58
To Make the First Decision
Return for Revision	2022-08-01 04:10
Revised	2022-08-30 03:41
Second Decision	2022-10-31 03:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2022-10-31 18:28
Articles in Press	2022-10-31 18:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2022-10-08 21:31
Typeset the Manuscript	2022-11-02 00:58
Publish the Manuscript Online	2022-11-15 10:19

ISSN	1948-5204 (online)
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Category	Oncology
Manuscript Type	Basic Study
Article Title	Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Ze-Xuan Fang, Chun-Lan Li, Zheng Wu, Yan-Yu Hou, Hua-Tao Wu and Jing Liu
ORCID	Author(s) ORCID Number Ze-Xuan Fang http://orcid.org/0000-0002-6100-9012 Chun-Lan Li http://orcid.org/0000-0002-1649-9059 Zheng Wu http://orcid.org/0000-0002-1393-7586 Yan-Yu Hou http://orcid.org/0000-0002-4249-8770 Hua-Tao Wu http://orcid.org/0000-0002-1640-6094 Jing Liu http://orcid.org/0000-0002-7483-4572
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81501539 Natural Science Foundation of Guangdong Province 2021A1515012180, 2016A030312008 Special Grant for Key Area Programs of Guangdong Department of Education 2021ZDZX2004 Science and Technology Special Project of Guangdong Province 210715216902829 “Dengfeng Project” for the construction of high-level hospitals in Guangdong Province-First Affiliated Hospital of Shantou University College Supporting Funding 202003-10
Corresponding Author	Jing Liu, MD, PhD, Academic Research, Associate Professor, Research Scientist, Senior Scientist, Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong Province, China. jliu12@stu.edu.cn
Key Words	Sine oculis homeobox homolog; Colorectal cancer; Development; Treatment; Expression; Prognostic indicator
Core Tip	This study systematically analyzed the expression pattern and prognostic value of sine oculis homeobox homolog (SIX) family members in colorectal cancer (CRC). It was found that the expression of SIX4 in CRC tissues positively correlated with the development of CRC and negatively correlated with overall survival. The top 50 SIX4-related genes were involved with oxidative phosphorylation and the respiratory chain signaling pathways. SIX4 may be a novel and potential therapeutic target for CRC.
Publish Date	2022-11-15 10:19
Citation	Fang ZX, Li CL, Wu Z, Hou YY, Wu HT, Liu J. Comprehensive analysis of the potential role and prognostic value of sine oculis homeobox homolog family in colorectal cancer. World J Gastrointest Oncol 2022; 14(11): 2138-2156
URL	https://www.wjgnet.com/1948-5204/full/v14/i11/2138.htm
DOI	https://dx.doi.org/10.4251/wjgo.v14.i11.2138

Full Article (PDF)	WJGO-14-2138.pdf
Full Article (Word)	WJGO-14-2138.docx
Manuscript File	78685_Auto_Edited-LM.docx
Answering Reviewers	78685-Answering reviewers.pdf
Audio Core Tip	78685-Audio core tip.mp3
Biostatistics Review Certificate	78685-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	78685-Conflict-of-interest statement.pdf
Copyright License Agreement	78685-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	78685-Grant application form(s).pdf
Institutional Review Board Approval Form or Document	78685-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	78685-Language certificate.pdf
Peer-review Report	78685-Peer-review(s).pdf
Scientific Misconduct Check	78685-Bing-Wang JJ-2.png
Scientific Editor Work List	78685-Scientific editor work list.pdf